Efficient synthesis of 5- and 6-tributylstannylindoles and their reactivity with acid chlorides in the Stille coupling reaction

Several 5- and 6-acylindoles have been synthesized in good yield by means of palladium catalyzed cross-coupling reactions between acid chloride derivatives and 5- or 6-tributylstannylindoles to give useful intermediates for the synthesis of analogues of biologically and pharmacologically active molecules. Several 5- and 6-acylindoles have been synthesized in good yield by means of palladium catalyzed cross-coupling reactions between acid chloride derivatives and 5- or 6-tributylstannylindoles to give useful intermediates for the synthesis of analogues of biologically and pharmacologically active molecules.