Determinants of survival in myelofibrosis patients undergoing allogeneic hematopoietic cell transplantation

We aimed to evaluate the determinants of survival in myelofibrosis patients undergoing allogeneic hematopoietic cell transplantation (allo-HCT) and to describe factors predicting the main post-HCT complications. This retrospective study by the European Society for Blood and Marrow Transplantation in...

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Veröffentlicht in:	Leukemia 2021-01, Vol.35 (1), p.215-224
Hauptverfasser:	Hernández-Boluda, Juan Carlos, Pereira, Arturo, Kröger, Nicolaus, Beelen, Dietrich, Robin, Marie, Bornhäuser, Martin, Angelucci, Emanuele, Vitek, Antonin, Blau, Igor Wolfgang, Niittyvuopio, Riitta, Finke, Jürgen, Cornelissen, Jan J., Passweg, Jakob, Dreger, Peter, Petersen, Eefke, Kanz, Lothar, Sanz, Jaime, Zuckerman, Tsila, Zinger, Nienke, Iacobelli, Simona, Hayden, Patrick, Czerw, Tomasz, McLornan, Donal, Yakoub-Agha, Ibrahim
Format:	Artikel
Sprache:	eng
Schlagworte:	692/308/2171 692/699/1541/1990/2331 Cancer Research Care and treatment Clinical decision making Complications Critical Care Medicine Decision making Development and progression Europe Evaluation Female Graft rejection Graft vs Host Disease - etiology Graft-versus-host reaction Grafting Grafts Hematology Hematopoietic Stem Cell Transplantation - adverse effects Hematopoietic Stem Cell Transplantation - methods Hematopoietic stem cells Histocompatibility antigen HLA Humans Intensive Internal Medicine Kaplan-Meier Estimate Life Sciences Male Medicine Medicine & Public Health Mortality Myelofibrosis Oncology Primary Myelofibrosis - diagnosis Primary Myelofibrosis - epidemiology Primary Myelofibrosis - mortality Primary Myelofibrosis - therapy Prognosis Proportional Hazards Models Recurrence Registries Retrospective Studies Risk Stem cell transplantation Survival Transplantation Transplantation, Homologous Transplants & implants Treatment Outcome
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Zusammenfassung:	We aimed to evaluate the determinants of survival in myelofibrosis patients undergoing allogeneic hematopoietic cell transplantation (allo-HCT) and to describe factors predicting the main post-HCT complications. This retrospective study by the European Society for Blood and Marrow Transplantation included 2916 myelofibrosis patients who underwent first allo-HCT from an HLA-identical sibling or unrelated donor between 2000 and 2016. After a median follow-up of 4.7 years from transplant, projected median survival of the series was 5.3 years. Factors independently associated with increased mortality were age ≥ 60 years and Karnofsky Performance Status
ISSN:	0887-6924 1476-5551
DOI:	10.1038/s41375-020-0815-z