Initial sequencing and analysis of the human genome

The human genome holds an extraordinary trove of information about human development, physiology, medicine and evolution. Here we report the results of an international collaboration to produce and make freely available a draft sequence of the human genome. We also present an initial analysis of the...

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Veröffentlicht in:	Nature 2001-02, Vol.409 (6822), p.860-921
Hauptverfasser:	Lander, E S, Linton, L M, Birren, B, Nusbaum, C, Zody, M C, Baldwin, J, Devon, K, Dewar, K, Doyle, M, FitzHugh, W, Funke, R, Gage, D, Harris, K, Heaford, A, Howland, J, Kann, L, Lehoczky, J, LeVine, R, McEwan, P, McKernan, K, Meldrim, J, Mesirov, J P, Miranda, C, Morris, W, Naylor, J, Raymond, C, Rosetti, M, Santos, R, Sheridan, A, Sougnez, C, Stange-Thomann, Y, Stojanovic, N, Subramanian, A, Wyman, D, Rogers, J, Sulston, J, Ainscough, R, Beck, S, Bentley, D, Burton, J, Clee, C, Carter, N, Coulson, A, Deadman, R, Deloukas, P, Dunham, A, Dunham, I, Durbin, R, French, L, Grafham, D, Gregory, S, Hubbard, T, Humphray, S, Hunt, A, Jones, M, Lloyd, C, McMurray, A, Matthews, L, Mercer, S, Milne, S, Mullikin, J C, Mungall, A, Plumb, R, Ross, M, Shownkeen, R, Sims, S, Waterston, R H, Wilson, R K, Hillier, L W, McPherson, J D, Marra, M A, Mardis, E R, Fulton, L A, Chinwalla, A T, Pepin, K H, Gish, W R, Chissoe, S L, Wendl, M C, Delehaunty, K D, Miner, T L, Delehaunty, A, Kramer, J B, Cook, L L, Fulton, R S, Johnson, D L, Minx, P J, Clifton, S W, Hawkins, T, Branscomb, E, Predki, P, Richardson, P, Wenning, S, Slezak, T, Doggett, N, Cheng, J F, Olsen, A, Lucas, S, Elkin, C, Uberbacher, E, Frazier, M
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Animals BASIC BIOLOGICAL SCIENCES Chromosome Mapping Conserved Sequence CpG Islands DATA ANALYSIS Databases, Factual Deoxyribonucleic acid DNA DNA SEQUENCING DNA Transposable Elements Drug Industry Evolution, Molecular Forecasting GC Rich Sequence Gene Duplication Genes Genetic Diseases, Inborn GENETICS Genetics, Medical Genome, Human Genomics Human Genome Project HUMAN POPULATIONS Humanities and Social Sciences Humans International cooperation Life Sciences multidisciplinary Mutation Original Article Physiology Private Sector Proteins - genetics Proteome Public Sector Repetitive Sequences, Nucleic Acid RNA - genetics Science Sequence Analysis, DNA - methods Species Specificity
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Beschreibung
Zusammenfassung:	The human genome holds an extraordinary trove of information about human development, physiology, medicine and evolution. Here we report the results of an international collaboration to produce and make freely available a draft sequence of the human genome. We also present an initial analysis of the data, describing some of the insights that can be gleaned from the sequence.
ISSN:	0028-0836 1476-4687
DOI:	10.1038/35057062