Binary Genetic Cassettes for Selecting XNA-Templated DNA Synthesis In Vivo

Hereditary information, coded in two bases, can be conveyed to DNA in vivo in the form of cyclohexenyl nucleic acid (CeNA), arabinofuranosyl nucleic acid (AraNA), and hexitol nucleic acid (HNA) messages. It was thus demonstrated that a binary genetic cassette can be used for the title process.

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Bibliographische Detailangaben
Veröffentlicht in:	Angewandte Chemie International Edition 2013-07, Vol.52 (31), p.8139-8143
Hauptverfasser:	Pezo, Valérie, Liu, Feng Wu, Abramov, Mikhail, Froeyen, Mathy, Herdewijn, Piet, Marlière, Philippe
Format:	Artikel
Sprache:	eng
Schlagworte:	Arabinose - chemistry Base Sequence Biomedical materials Cassettes Catalytic Domain Cyclohexenes - chemistry Deoxyribonucleic acid DNA - chemical synthesis DNA - chemistry Escherichia coli - enzymology Escherichia coli Proteins - chemistry Escherichia coli Proteins - genetics Escherichia coli Proteins - metabolism gene expression Genetics hypoxanthine Hypoxanthine - chemistry In vivo testing In vivo tests Life Sciences Messages Nucleic acids Nucleotides - chemistry Nucleotides - metabolism Sugar Alcohols - chemistry Thymidylate Synthase - chemistry Thymidylate Synthase - genetics Thymidylate Synthase - metabolism thymidylate synthetase uracil Xenobiotics - chemistry
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Beschreibung
Zusammenfassung:	Hereditary information, coded in two bases, can be conveyed to DNA in vivo in the form of cyclohexenyl nucleic acid (CeNA), arabinofuranosyl nucleic acid (AraNA), and hexitol nucleic acid (HNA) messages. It was thus demonstrated that a binary genetic cassette can be used for the title process.
ISSN:	1433-7851 1521-3773
DOI:	10.1002/anie.201303288