The SRA protein UHRF1 promotes epigenetic crosstalks and is involved in prostate cancer progression

Epigenetic silencing of tumour suppressor genes is an important mechanism involved in cell transformation and tumour progression. The Set and RING-finger-associated domain-containing protein UHRF1 might be an important link between different epigenetic pathways. Here, we report that UHRF1 is frequen...

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Veröffentlicht in:	Oncogene 2012-11, Vol.31 (46), p.4878-4887
Hauptverfasser:	Babbio, F, Pistore, C, Curti, L, Castiglioni, I, Kunderfranco, P, Brino, L, Oudet, P, Seiler, R, Thalman, G N, Roggero, E, Sarti, M, Pinton, S, Mello-Grand, M, Chiorino, G, Catapano, C V, Carbone, G M, Bonapace, I M
Format:	Artikel
Sprache:	eng
Schlagworte:	631/208/2489/2487/2486 631/67/589/466 692/420/755 Acetylation Analysis Apoptosis Biochemistry, Molecular Biology CCAAT-Enhancer-Binding Proteins - genetics CCAAT-Enhancer-Binding Proteins - metabolism Cell Biology Cell Growth Processes - physiology Cell Line, Tumor Cell proliferation Cellular biology Cellular proteins Data processing Development and progression Disease Progression DNA Methylation DNA methyltransferase DNA microarrays DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Enhancer of Zeste Homolog 2 Protein Epigenesis, Genetic Epigenetic inheritance Epigenetics Gene expression Gene Expression Regulation, Neoplastic Gene Silencing Genes Genes, Tumor Suppressor Genetic aspects HEK293 Cells Histone methyltransferase Histone Methyltransferases Histone-Lysine N-Methyltransferase - genetics Histone-Lysine N-Methyltransferase - metabolism Histones Histones - genetics Histones - metabolism Human Genetics Humans Immunohistochemistry Immunoprecipitation Immunoprecipitation - methods Internal Medicine Life Sciences Male Medicine Medicine & Public Health Methylation Oncology original-article Pathogenesis Physiological aspects Polycomb Repressive Complex 2 - genetics Polycomb Repressive Complex 2 - metabolism Promoter Regions, Genetic Promoters Prostate cancer Prostatectomy Prostatic Neoplasms - genetics Prostatic Neoplasms - metabolism Prostatic Neoplasms - pathology Proteins Risk factors Transformation Tumor suppressor genes Tumors
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Zusammenfassung:	Epigenetic silencing of tumour suppressor genes is an important mechanism involved in cell transformation and tumour progression. The Set and RING-finger-associated domain-containing protein UHRF1 might be an important link between different epigenetic pathways. Here, we report that UHRF1 is frequently overexpressed in human prostate tumours and has an important role in prostate cancer pathogenesis and progression. Analysis of human prostate cancer samples by microarrays and immunohistochemistry showed increased expression of UHRF1 in about half of the cases. Moreover, UHRF1 expression was associated with reduced overall survival after prostatectomy in patients with organ-confined prostate tumours ( P
ISSN:	0950-9232 1476-5594
DOI:	10.1038/onc.2011.641