Muscle oxygen supply impairment during maximal exercise in patients undergoing dialysis therapy

Muscle oxygen supply impairment during maximal exercise in patients undergoing dialysis therapy

This study aimed to investigate whether Chronic Kidney Disease (CKD) influences O2 supply including O2 delivery and release to the active muscles during maximal physical exercise. Twelve CKD patients undergoing dialysis therapy (HD group) and twelve healthy adults (CTR group) performed an incrementa...

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Veröffentlicht in:Respiratory physiology & neurobiology 2024-01, Vol.319, p.104169-104169, Article 104169
Hauptverfasser: Machfer, Amal, Tagougui, Sémah, Fekih, Nadia, Ben Haj Hassen, Hayfa, Amor, Hassen Ibn Hadj, Bouzid, Mohamed Amine, Chtourou, Hamdi
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Chronic kidney disease
Exercise
Hemodynamic
Life Sciences
NIRS
VO2peak
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container_title Respiratory physiology & neurobiology
container_volume 319
creator Machfer, Amal
Tagougui, Sémah
Fekih, Nadia
Ben Haj Hassen, Hayfa
Amor, Hassen Ibn Hadj
Bouzid, Mohamed Amine
Chtourou, Hamdi
description This study aimed to investigate whether Chronic Kidney Disease (CKD) influences O2 supply including O2 delivery and release to the active muscles during maximal physical exercise. Twelve CKD patients undergoing dialysis therapy (HD group) and twelve healthy adults (CTR group) performed an incremental exercise test to determine maximal oxygen uptake (VO2peak). Throughout the exercise, near-infrared spectroscopy allowed the investigation of changes in oxyhemoglobin (∆O2Hb), deoxyhemoglobin (∆HHb), and total hemoglobin (∆THb) in the vastus lateralis muscle. VO2peak was significantly lower in HD group. In addition, HD patients had impaired changes in muscular oxygenation (∆HHb and ∆O2Hb) and blood volume (∆THb) during the exercise (p 
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[Display omitted] •Aerobic fitness, as reflected by maximal oxygen uptake (VO2peak), is impaired in patients undergoing dialysis therapy (HD).•We investigated the relationship between oxygen supply to the active muscles and VO2peak level in HD patients.•Our results showed a significant relationship between VO2peak and muscle blood volume during exercise.•This finding support muscle hypoperfusion as a primary cause of the reduction in aerobic fitness characterizing HD patients.</description><identifier>ISSN: 1569-9048</identifier><identifier>EISSN: 1878-1519</identifier><identifier>DOI: 10.1016/j.resp.2023.104169</identifier><identifier>PMID: 37813323</identifier><language>eng</language><publisher>Elsevier B.V</publisher><subject>Chronic kidney disease ; Exercise ; Hemodynamic ; Life Sciences ; NIRS ; VO2peak</subject><ispartof>Respiratory physiology &amp; neurobiology, 2024-01, Vol.319, p.104169-104169, Article 104169</ispartof><rights>2023 Elsevier B.V.</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c367t-a2a36f3ba2a1c869f94f26944a619bcbce0bffa86c0409434dee603479e984793</citedby><cites>FETCH-LOGICAL-c367t-a2a36f3ba2a1c869f94f26944a619bcbce0bffa86c0409434dee603479e984793</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S156990482300157X$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,776,780,881,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://hal.univ-lille.fr/hal-04313242$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Machfer, Amal</creatorcontrib><creatorcontrib>Tagougui, Sémah</creatorcontrib><creatorcontrib>Fekih, Nadia</creatorcontrib><creatorcontrib>Ben Haj Hassen, Hayfa</creatorcontrib><creatorcontrib>Amor, Hassen Ibn Hadj</creatorcontrib><creatorcontrib>Bouzid, Mohamed Amine</creatorcontrib><creatorcontrib>Chtourou, Hamdi</creatorcontrib><title>Muscle oxygen supply impairment during maximal exercise in patients undergoing dialysis therapy</title><title>Respiratory physiology &amp; neurobiology</title><description>This study aimed to investigate whether Chronic Kidney Disease (CKD) influences O2 supply including O2 delivery and release to the active muscles during maximal physical exercise. 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[Display omitted] •Aerobic fitness, as reflected by maximal oxygen uptake (VO2peak), is impaired in patients undergoing dialysis therapy (HD).•We investigated the relationship between oxygen supply to the active muscles and VO2peak level in HD patients.•Our results showed a significant relationship between VO2peak and muscle blood volume during exercise.•This finding support muscle hypoperfusion as a primary cause of the reduction in aerobic fitness characterizing HD patients.</abstract><pub>Elsevier B.V</pub><pmid>37813323</pmid><doi>10.1016/j.resp.2023.104169</doi><tpages>1</tpages></addata></record>
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subjects Chronic kidney disease
Exercise
Hemodynamic
Life Sciences
NIRS
VO2peak
title Muscle oxygen supply impairment during maximal exercise in patients undergoing dialysis therapy
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