Muscle oxygen supply impairment during maximal exercise in patients undergoing dialysis therapy

Muscle oxygen supply impairment during maximal exercise in patients undergoing dialysis therapy

This study aimed to investigate whether Chronic Kidney Disease (CKD) influences O2 supply including O2 delivery and release to the active muscles during maximal physical exercise. Twelve CKD patients undergoing dialysis therapy (HD group) and twelve healthy adults (CTR group) performed an incrementa...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Respiratory physiology & neurobiology 2024-01, Vol.319, p.104169-104169, Article 104169
Hauptverfasser: Machfer, Amal, Tagougui, Sémah, Fekih, Nadia, Ben Haj Hassen, Hayfa, Amor, Hassen Ibn Hadj, Bouzid, Mohamed Amine, Chtourou, Hamdi
Format: Artikel
Sprache:eng
Schlagworte:
Chronic kidney disease
Exercise
Hemodynamic
Life Sciences
NIRS
VO2peak
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:This study aimed to investigate whether Chronic Kidney Disease (CKD) influences O2 supply including O2 delivery and release to the active muscles during maximal physical exercise. Twelve CKD patients undergoing dialysis therapy (HD group) and twelve healthy adults (CTR group) performed an incremental exercise test to determine maximal oxygen uptake (VO2peak). Throughout the exercise, near-infrared spectroscopy allowed the investigation of changes in oxyhemoglobin (∆O2Hb), deoxyhemoglobin (∆HHb), and total hemoglobin (∆THb) in the vastus lateralis muscle. VO2peak was significantly lower in HD group. In addition, HD patients had impaired changes in muscular oxygenation (∆HHb and ∆O2Hb) and blood volume (∆THb) during the exercise (p 
ISSN:1569-9048
1878-1519
DOI:10.1016/j.resp.2023.104169