When transcription initiation meets chromatin

Gene transcription initiation is a highly regulated process in which Pol II and general transcription factors assemble into a pre-initiation complex. Structural studies of yeast and human initiation complexes shed light on the role of the first nucleosome flanking gene promoters in controlling the t...

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Veröffentlicht in:	Nature structural & molecular biology 2023-02, Vol.30 (2), p.131-133
1. Verfasser:	Schultz, Patrick
Format:	Artikel
Sprache:	eng
Schlagworte:	631/337/572 631/535/1258/1259 Biochemistry Biological Microscopy Biomedical and Life Sciences Chromatin Enzymes Gene expression Genomes Histones - metabolism Initiation complex Life Sciences Membrane Biology Molecular biology News & Views news-and-views Protein Structure Proteins RNA polymerase Transcription factors Transcription initiation Transcription, Genetic Yeast Yeasts
Online-Zugang:	Volltext
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Beschreibung
Zusammenfassung:	Gene transcription initiation is a highly regulated process in which Pol II and general transcription factors assemble into a pre-initiation complex. Structural studies of yeast and human initiation complexes shed light on the role of the first nucleosome flanking gene promoters in controlling the transcription machinery.
ISSN:	1545-9993 1545-9985
DOI:	10.1038/s41594-022-00916-2