Chloroquine Inhibits the Release of Inflammatory Cytokines by Human Lung Explants

Chloroquine Inhibits the Release of Inflammatory Cytokines by Human Lung Explants

Abstract On human lung parenchymal explants, chloroquine concentration clinically achievable in the lung (100 µM) inhibited the lipopolysaccharide-induced release of TNF-ɑ (by 76%), IL-6 (by 68%), CCL2 (by 72%), and CCL3 (by 67%). Besides its antiviral activity, chloroquine might also mitigate the c...

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Veröffentlicht in:Clinical infectious diseases 2020-10, Vol.71 (16), p.2265-2268
Hauptverfasser: Grassin-Delyle, Stanislas, Salvator, Hélène, Brollo, Marion, Catherinot, Emilie, Sage, Edouard, Couderc, Louis-Jean, Naline, Emmanuel, Devillier, Philippe
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container_end_page 2268
container_issue 16
container_start_page 2265
container_title Clinical infectious diseases
container_volume 71
creator Grassin-Delyle, Stanislas
Salvator, Hélène
Brollo, Marion
Catherinot, Emilie
Sage, Edouard
Couderc, Louis-Jean
Naline, Emmanuel
Devillier, Philippe
description Abstract On human lung parenchymal explants, chloroquine concentration clinically achievable in the lung (100 µM) inhibited the lipopolysaccharide-induced release of TNF-ɑ (by 76%), IL-6 (by 68%), CCL2 (by 72%), and CCL3 (by 67%). Besides its antiviral activity, chloroquine might also mitigate the cytokine storm associated with severe pneumonia caused by coronaviruses.
doi_str_mv 10.1093/cid/ciaa546
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source Oxford University Press Journals All Titles (1996-Current); Alma/SFX Local Collection; EZB Electronic Journals Library
subjects Life Sciences
title Chloroquine Inhibits the Release of Inflammatory Cytokines by Human Lung Explants
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