Chloroquine Inhibits the Release of Inflammatory Cytokines by Human Lung Explants

Chloroquine Inhibits the Release of Inflammatory Cytokines by Human Lung Explants

Abstract On human lung parenchymal explants, chloroquine concentration clinically achievable in the lung (100 µM) inhibited the lipopolysaccharide-induced release of TNF-ɑ (by 76%), IL-6 (by 68%), CCL2 (by 72%), and CCL3 (by 67%). Besides its antiviral activity, chloroquine might also mitigate the c...

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Veröffentlicht in:Clinical infectious diseases 2020-10, Vol.71 (16), p.2265-2268
Hauptverfasser: Grassin-Delyle, Stanislas, Salvator, Hélène, Brollo, Marion, Catherinot, Emilie, Sage, Edouard, Couderc, Louis-Jean, Naline, Emmanuel, Devillier, Philippe
Format: Artikel
Sprache:eng
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Life Sciences
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Zusammenfassung:Abstract On human lung parenchymal explants, chloroquine concentration clinically achievable in the lung (100 µM) inhibited the lipopolysaccharide-induced release of TNF-ɑ (by 76%), IL-6 (by 68%), CCL2 (by 72%), and CCL3 (by 67%). Besides its antiviral activity, chloroquine might also mitigate the cytokine storm associated with severe pneumonia caused by coronaviruses.
ISSN:1058-4838
1537-6591
DOI:10.1093/cid/ciaa546