Ets-1 expression promotes epithelial cell transformation by inducing migration, invasion and anchorage-independent growth

Ets-1 is the prototype of the family of ETS transcription factors. In human tumors, Ets-1 is expressed in endothelial cells and fibroblasts of the tumor stroma and is proposed to play a role in tumor vascularization and invasion by upregulating expression of matrix-degrading proteases. In human carc...

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Veröffentlicht in:Oncogene 2005-08, Vol.24 (34), p.5384-5388
Hauptverfasser: Hahne, Jens Claus, Okuducu, Ali Fuat, Kaminski, Annette, Florin, Alexandra, Soncin, Fabrice, Wernert, Nicolas
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Sprache:eng
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Zusammenfassung:Ets-1 is the prototype of the family of ETS transcription factors. In human tumors, Ets-1 is expressed in endothelial cells and fibroblasts of the tumor stroma and is proposed to play a role in tumor vascularization and invasion by upregulating expression of matrix-degrading proteases. In human carcinomas, Ets-1 is also expressed by neoplastic cells, but little is known about the functional implications of this observation. We have addressed the role of Ets-1 in epithelial HeLa tumor cells by selecting stably Ets-1 over and underexpressing HeLa cells. Ets-1 expression increases the transformed phenotype of HeLa cells, by promoting cell migration, invasion and anchorage-independent growth, while Ets-1 downregulation reduces cell attachment. In correlation with these results, Ets-1 upregulation increases integrin β 2 expression but not that of other integrins. These results suggest that, in addition to its role in the tumor stroma, Ets-1 may also promote tumor development and progression by increasing neoplastic transformation.
ISSN:0950-9232
1476-5594
DOI:10.1038/sj.onc.1208761