Anticancer platinum-based photo-oxidants in a new light

Pharmacologically inactive prodrugs that can be activated by near-infrared light are attractive candidates for clinical applications. Now, platinum-based photo-oxidants have been shown to eradicate tumours in mice with a new mode of action.

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Bibliographische Detailangaben
Veröffentlicht in:	Nature chemistry 2023-07, Vol.15 (7), p.896-898
Hauptverfasser:	Vigueras, Gloria, Gasser, Gilles
Format:	Artikel
Sprache:	eng
Schlagworte:	639/638/263/49 639/638/309/2144 Analytical Chemistry Antineoplastic Agents - pharmacology Apoptosis Biochemistry Cancer therapies Chemical Sciences Chemistry Chemistry and Materials Science Chemistry/Food Science Chemotherapy Drugs Endoplasmic reticulum FDA approval Hypoxia Inorganic Chemistry Lasers Ligands Light Light therapy Lipids Medicinal Chemistry Metastasis Mode of action News & Views news-and-views Organic Chemistry Oxidants Oxidation Oxidizing agents Physical Chemistry Platinum Prodrugs Proteins Stem cells Tumors
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Beschreibung
Zusammenfassung:	Pharmacologically inactive prodrugs that can be activated by near-infrared light are attractive candidates for clinical applications. Now, platinum-based photo-oxidants have been shown to eradicate tumours in mice with a new mode of action.
ISSN:	1755-4330 1755-4349 1755-4349
DOI:	10.1038/s41557-023-01250-w