Structure–activity relationships of methylene or terminal side chain modified retinoids on the differentiation and cell death signaling in NB4 promyelocytic leukemia cells
New structure–activity relationships of a series of methylene or side chain modified retinoids are investigated on the basis of their selective RAR/RXR binding profile. New structure–activity relationships of a series of methylene or side chain modified retinoids on NB4 acute promyelocytic leukemia...
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| Veröffentlicht in: | Bioorganic & medicinal chemistry letters 2004-08, Vol.14 (16), p.4257-4261 |
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| container_end_page | 4261 |
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| container_issue | 16 |
| container_start_page | 4257 |
| container_title | Bioorganic & medicinal chemistry letters |
| container_volume | 14 |
| creator | Ivanova, Diana Rossin, Aurélie Gronemeyer, Hinrich Valla, Alain Cartier, Dominique Le Guillou, Régis Labia, Roger |
| description | New structure–activity relationships of a series of methylene or side chain modified retinoids are investigated on the basis of their selective RAR/RXR binding profile.
New structure–activity relationships of a series of methylene or side chain modified retinoids on NB4 acute promyelocytic leukemia cells are investigated. The differentiation- and apoptosis-inducing potential of these compounds is analyzed on the basis of their selective retinoic acid receptor binding profile. |
| doi_str_mv | 10.1016/j.bmcl.2004.06.002 |
| format | Article |
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New structure–activity relationships of a series of methylene or side chain modified retinoids on NB4 acute promyelocytic leukemia cells are investigated. The differentiation- and apoptosis-inducing potential of these compounds is analyzed on the basis of their selective retinoic acid receptor binding profile.</description><identifier>ISSN: 0960-894X</identifier><identifier>EISSN: 1464-3405</identifier><identifier>DOI: 10.1016/j.bmcl.2004.06.002</identifier><identifier>PMID: 15261282</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>Antineoplastic agents ; Apoptosis ; Biochemistry, Molecular Biology ; Biological and medical sciences ; Cell Death ; Cell Differentiation ; Cell Line, Tumor ; Differentiation ; General aspects ; Humans ; Hydrocarbons ; Leukemia ; Leukemia, Promyelocytic, Acute - pathology ; Life Sciences ; Medical sciences ; Methane - analogs & derivatives ; Methane - chemistry ; Methane - pharmacology ; Pharmacology. Drug treatments ; RAR selectivity ; Retinoids ; Retinoids - chemistry ; Retinoids - pharmacology ; Rexinoids ; Structure-Activity Relationship</subject><ispartof>Bioorganic & medicinal chemistry letters, 2004-08, Vol.14 (16), p.4257-4261</ispartof><rights>2004 Elsevier Ltd</rights><rights>2005 INIST-CNRS</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c416t-1fbd6df64b2167772aa101962d01b3fe1b9e35f9d8f5cd1a902199ee30557b473</citedby><cites>FETCH-LOGICAL-c416t-1fbd6df64b2167772aa101962d01b3fe1b9e35f9d8f5cd1a902199ee30557b473</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.bmcl.2004.06.002$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,780,784,885,3548,27923,27924,45994</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15956314$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15261282$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.science/hal-04139894$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Ivanova, Diana</creatorcontrib><creatorcontrib>Rossin, Aurélie</creatorcontrib><creatorcontrib>Gronemeyer, Hinrich</creatorcontrib><creatorcontrib>Valla, Alain</creatorcontrib><creatorcontrib>Cartier, Dominique</creatorcontrib><creatorcontrib>Le Guillou, Régis</creatorcontrib><creatorcontrib>Labia, Roger</creatorcontrib><title>Structure–activity relationships of methylene or terminal side chain modified retinoids on the differentiation and cell death signaling in NB4 promyelocytic leukemia cells</title><title>Bioorganic & medicinal chemistry letters</title><addtitle>Bioorg Med Chem Lett</addtitle><description>New structure–activity relationships of a series of methylene or side chain modified retinoids are investigated on the basis of their selective RAR/RXR binding profile.
New structure–activity relationships of a series of methylene or side chain modified retinoids on NB4 acute promyelocytic leukemia cells are investigated. The differentiation- and apoptosis-inducing potential of these compounds is analyzed on the basis of their selective retinoic acid receptor binding profile.</description><subject>Antineoplastic agents</subject><subject>Apoptosis</subject><subject>Biochemistry, Molecular Biology</subject><subject>Biological and medical sciences</subject><subject>Cell Death</subject><subject>Cell Differentiation</subject><subject>Cell Line, Tumor</subject><subject>Differentiation</subject><subject>General aspects</subject><subject>Humans</subject><subject>Hydrocarbons</subject><subject>Leukemia</subject><subject>Leukemia, Promyelocytic, Acute - pathology</subject><subject>Life Sciences</subject><subject>Medical sciences</subject><subject>Methane - analogs & derivatives</subject><subject>Methane - chemistry</subject><subject>Methane - pharmacology</subject><subject>Pharmacology. Drug treatments</subject><subject>RAR selectivity</subject><subject>Retinoids</subject><subject>Retinoids - chemistry</subject><subject>Retinoids - pharmacology</subject><subject>Rexinoids</subject><subject>Structure-Activity Relationship</subject><issn>0960-894X</issn><issn>1464-3405</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kcGKFDEQhhtR3HX1BTxILgoeZkzS6fQ0eFkXdYVBDyp4C-mkervGdDIm6YG5-Q4-hy_lk5jZGdSTp4Li-z-K-qvqMaNLRpl8sVn2k3FLTqlYUrmklN-pzpmQYlEL2tytzmkn6WLViS9n1YOUNpQyQYW4X52xhkvGV_y8-vkxx9nkOcKv7z-0ybjDvCcRnM4YfBpxm0gYyAR53DvwQEIkGeKEXjuS0AIxo0ZPpmBxQLAlmtEHtCXmSR6BlP0AEXzGWyXR3hIDzhELOo_FcVNU6G9Isbx_Jcg2hmkPLph9RkMczF9hQn0bSQ-re4N2CR6d5kX1-c3rT1fXi_WHt--uLtcLI5jMCzb0VtpBip4z2bYt17o8rJPcUtbXA7C-g7oZOrsaGmOZ7ihnXQdQ06Zpe9HWF9Xzo3fUTm0jTjruVdCori_X6rCjgtVd-eyOFfbZkS2Hf5shZTVhOlyrPYQ5KSnbIq95AfkRNDGkFGH4Y2ZUHQpVG3UoVB0KVVSqUmgJPTnZ534C-zdyarAAT0-ATka7IWpvMP3DdY2smSjcyyMH5W87hKiSQfAGLEYwWdmA_7vjN1JnwyI</recordid><startdate>20040816</startdate><enddate>20040816</enddate><creator>Ivanova, Diana</creator><creator>Rossin, Aurélie</creator><creator>Gronemeyer, Hinrich</creator><creator>Valla, Alain</creator><creator>Cartier, Dominique</creator><creator>Le Guillou, Régis</creator><creator>Labia, Roger</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>1XC</scope></search><sort><creationdate>20040816</creationdate><title>Structure–activity relationships of methylene or terminal side chain modified retinoids on the differentiation and cell death signaling in NB4 promyelocytic leukemia cells</title><author>Ivanova, Diana ; Rossin, Aurélie ; Gronemeyer, Hinrich ; Valla, Alain ; Cartier, Dominique ; Le Guillou, Régis ; Labia, Roger</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c416t-1fbd6df64b2167772aa101962d01b3fe1b9e35f9d8f5cd1a902199ee30557b473</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Antineoplastic agents</topic><topic>Apoptosis</topic><topic>Biochemistry, Molecular Biology</topic><topic>Biological and medical sciences</topic><topic>Cell Death</topic><topic>Cell Differentiation</topic><topic>Cell Line, Tumor</topic><topic>Differentiation</topic><topic>General aspects</topic><topic>Humans</topic><topic>Hydrocarbons</topic><topic>Leukemia</topic><topic>Leukemia, Promyelocytic, Acute - pathology</topic><topic>Life Sciences</topic><topic>Medical sciences</topic><topic>Methane - analogs & derivatives</topic><topic>Methane - chemistry</topic><topic>Methane - pharmacology</topic><topic>Pharmacology. Drug treatments</topic><topic>RAR selectivity</topic><topic>Retinoids</topic><topic>Retinoids - chemistry</topic><topic>Retinoids - pharmacology</topic><topic>Rexinoids</topic><topic>Structure-Activity Relationship</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ivanova, Diana</creatorcontrib><creatorcontrib>Rossin, Aurélie</creatorcontrib><creatorcontrib>Gronemeyer, Hinrich</creatorcontrib><creatorcontrib>Valla, Alain</creatorcontrib><creatorcontrib>Cartier, Dominique</creatorcontrib><creatorcontrib>Le Guillou, Régis</creatorcontrib><creatorcontrib>Labia, Roger</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><jtitle>Bioorganic & medicinal chemistry letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ivanova, Diana</au><au>Rossin, Aurélie</au><au>Gronemeyer, Hinrich</au><au>Valla, Alain</au><au>Cartier, Dominique</au><au>Le Guillou, Régis</au><au>Labia, Roger</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Structure–activity relationships of methylene or terminal side chain modified retinoids on the differentiation and cell death signaling in NB4 promyelocytic leukemia cells</atitle><jtitle>Bioorganic & medicinal chemistry letters</jtitle><addtitle>Bioorg Med Chem Lett</addtitle><date>2004-08-16</date><risdate>2004</risdate><volume>14</volume><issue>16</issue><spage>4257</spage><epage>4261</epage><pages>4257-4261</pages><issn>0960-894X</issn><eissn>1464-3405</eissn><abstract>New structure–activity relationships of a series of methylene or side chain modified retinoids are investigated on the basis of their selective RAR/RXR binding profile.
New structure–activity relationships of a series of methylene or side chain modified retinoids on NB4 acute promyelocytic leukemia cells are investigated. The differentiation- and apoptosis-inducing potential of these compounds is analyzed on the basis of their selective retinoic acid receptor binding profile.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>15261282</pmid><doi>10.1016/j.bmcl.2004.06.002</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0960-894X |
| ispartof | Bioorganic & medicinal chemistry letters, 2004-08, Vol.14 (16), p.4257-4261 |
| issn | 0960-894X 1464-3405 |
| language | eng |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Antineoplastic agents Apoptosis Biochemistry, Molecular Biology Biological and medical sciences Cell Death Cell Differentiation Cell Line, Tumor Differentiation General aspects Humans Hydrocarbons Leukemia Leukemia, Promyelocytic, Acute - pathology Life Sciences Medical sciences Methane - analogs & derivatives Methane - chemistry Methane - pharmacology Pharmacology. Drug treatments RAR selectivity Retinoids Retinoids - chemistry Retinoids - pharmacology Rexinoids Structure-Activity Relationship |
| title | Structure–activity relationships of methylene or terminal side chain modified retinoids on the differentiation and cell death signaling in NB4 promyelocytic leukemia cells |
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