Structure–activity relationships of methylene or terminal side chain modified retinoids on the differentiation and cell death signaling in NB4 promyelocytic leukemia cells

New structure–activity relationships of a series of methylene or side chain modified retinoids are investigated on the basis of their selective RAR/RXR binding profile. New structure–activity relationships of a series of methylene or side chain modified retinoids on NB4 acute promyelocytic leukemia...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2004-08, Vol.14 (16), p.4257-4261
Hauptverfasser:	Ivanova, Diana, Rossin, Aurélie, Gronemeyer, Hinrich, Valla, Alain, Cartier, Dominique, Le Guillou, Régis, Labia, Roger
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic agents Apoptosis Biochemistry, Molecular Biology Biological and medical sciences Cell Death Cell Differentiation Cell Line, Tumor Differentiation General aspects Humans Hydrocarbons Leukemia Leukemia, Promyelocytic, Acute - pathology Life Sciences Medical sciences Methane - analogs & derivatives Methane - chemistry Methane - pharmacology Pharmacology. Drug treatments RAR selectivity Retinoids Retinoids - chemistry Retinoids - pharmacology Rexinoids Structure-Activity Relationship
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Zusammenfassung:	New structure–activity relationships of a series of methylene or side chain modified retinoids are investigated on the basis of their selective RAR/RXR binding profile. New structure–activity relationships of a series of methylene or side chain modified retinoids on NB4 acute promyelocytic leukemia cells are investigated. The differentiation- and apoptosis-inducing potential of these compounds is analyzed on the basis of their selective retinoic acid receptor binding profile.
ISSN:	0960-894X 1464-3405
DOI:	10.1016/j.bmcl.2004.06.002