Molecular Basis for Feedback Regulation of Bile Acid Synthesis by Nuclear Receptors

The catabolism of cholesterol into bile acids is regulated by oxysterols and bile acids, which induce or repress transcription of the pathway's rate-limiting enzyme cholesterol 7α-hydroxylase (CYP7A1). The nuclear receptor LXRα binds oxysterols and mediates feed-forward induction. Here, we show...

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Veröffentlicht in:	Molecular cell 2000-09, Vol.6 (3), p.507-515
Hauptverfasser:	Lu, Timothy T., Makishima, Makoto, Repa, Joyce J., Schoonjans, Kristina, Kerr, Thomas A., Auwerx, Johan, Mangelsdorf, David J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals bile acids Bile Acids and Salts - biosynthesis Biochemistry, Molecular Biology Cells, Cultured Cholesterol - metabolism Cholesterol 7-alpha-Hydroxylase - genetics Cholesterol 7-alpha-Hydroxylase - metabolism cholesterol 7^a-hydroxylase CYP7A1 gene DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Feedback - physiology FXR protein Gene Expression Regulation, Enzymologic - physiology Homeostasis - physiology Humans Kidney - cytology Life Sciences Liver X Receptors LRH-1 protein Mice Orphan Nuclear Receptors Promoter Regions, Genetic - physiology Receptors, Cytoplasmic and Nuclear - genetics Receptors, Cytoplasmic and Nuclear - metabolism Repressor Proteins - genetics Repressor Proteins - metabolism SHP protein Transcription Factors - genetics Transcription Factors - metabolism Transcription, Genetic - physiology
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