A single-cell chromatin map of human embryos

The transition from a fertilized egg to a pluripotent and transcriptionally independent embryo requires multi-layered chromatin regulation. A study now provides simultaneous profiling of chromatin accessibility and DNA methylation in human preimplantation embryos at single-cell resolution.

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Bibliographische Detailangaben
Veröffentlicht in:	Nature cell biology 2018-07, Vol.20 (7), p.742-744
Hauptverfasser:	Pérez-Palacios, Raquel, Bourc’his, Deborah
Format:	Artikel
Sprache:	eng
Schlagworte:	631/136/2086 631/337/100/101 631/337/176/1988 Biomedical and Life Sciences Cancer Research Cell Biology Chromatin Criminal investigation Deoxyribonucleic acid Developmental Biology DNA DNA methylation Embryo Embryonic development Embryos Genetic aspects Genetic research Genomes Genomics Human embryo Life Sciences Methylation Multilayers News & Views news-and-views Physiological aspects Pluripotency Sperm Stem Cells Transcription Universities and colleges
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Beschreibung
Zusammenfassung:	The transition from a fertilized egg to a pluripotent and transcriptionally independent embryo requires multi-layered chromatin regulation. A study now provides simultaneous profiling of chromatin accessibility and DNA methylation in human preimplantation embryos at single-cell resolution.
ISSN:	1465-7392 1476-4679
DOI:	10.1038/s41556-018-0134-z