Nanoparticles: The new promise for region-specific targeting of microglia

Microglia researchers are constantly looking for new targeting tools that are more precise in time and space. In this article, Guo et al. present the results of their latest study in which they develop nanoparticles capable of targeting microglia with high spatial specificity and delivering siRNAs to alter the transcriptome profile of the cells. Although certain obstacles remain, this study is very promising in the race for new tools to manipulate microglial activity locally in the brain. Microglia researchers are constantly looking for new targeting tools that are more precise in time and space. In this article, Guo et al. present the results of their latest study in which they develop nanoparticles capable of targeting microglia with high spatial specificity and delivering siRNAs to alter the transcriptome profile of the cells. Although certain obstacles remain, this study is very promising in the race for new tools to manipulate microglial activity locally in the brain.