Human Erythrocytes Covered with Magnetic Core-Shell Nanoparticles for Multimodal Imaging

Surface functionalization of human red blood cells (hRBCs) with fluorescent and magnetic silica core‐shell nanoparticles is used to design a carrier suitable for multimodal imaging with a long circulating time. The coated magnetic hRBCs show no hemolytic activity, while the advantage of the affinity...

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Veröffentlicht in:	Advanced healthcare materials 2013-09, Vol.2 (9), p.1209-1212
Hauptverfasser:	Laurencin, Mathieu, Cam, Nithavong, Georgelin, Thomas, Clément, Olivier, Autret, Gwennhael, Siaugue, Jean-Michel, Ménager, Christine
Format:	Artikel
Sprache:	eng
Schlagworte:	Affinity Animals Chemical Sciences Circulating Coating Contrast Media - chemistry core-shell magnetic nanoparticles Erythrocytes - chemistry Ferric Compounds - chemistry Fluorescein-5-isothiocyanate - chemistry Human human red blood cells Humans Imaging Liver - diagnostic imaging Magnetic Resonance Imaging Magnetite Nanoparticles - chemistry Mice Microscopy, Confocal multimodal imaging Nanoparticles Radiography Silicon dioxide Silicon Dioxide - chemistry Spleen - diagnostic imaging Surface chemistry surface decoration
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Zusammenfassung:	Surface functionalization of human red blood cells (hRBCs) with fluorescent and magnetic silica core‐shell nanoparticles is used to design a carrier suitable for multimodal imaging with a long circulating time. The coated magnetic hRBCs show no hemolytic activity, while the advantage of the affinity of proteins for silica allows a further coating.
ISSN:	2192-2640 2192-2659
DOI:	10.1002/adhm.201200384