Electrogenerated Nickel Catalyst for C–N Cross-Coupling

Arylamines represent a class of compounds widely found in natural products and pharmaceuticals. Among methodologies devoted to their synthesis, nickel-catalyzed amination of aryl halides constitutes one of the most employed conventional strategies. However, C–N cross-couplings often involve elaborated nickel complexes, which are expensive and/or air and moisture sensitive. To circumvent this issue, we herein report an electrochemical method based on a sacrificial anode process to in situ generate a catalytic amount of nickel salts allowing amination of aryl halides. The approach, simple to set up, proceeds under mild reaction conditions and enables access to a large panel of arylamines.