Low-level viral loads and virological failure in the integrase strand transfer era

Low-level viral loads and virological failure in the integrase strand transfer era

Abstract Objectives To analyse the occurrence of virological failure (VF) in patients starting ART with an integrase strand transfer inhibitor (INSTI)-based regimen in recent years, in relation with previous episodes of low-level viral load (LLVL). Patients and methods Patients starting a first ART...

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Veröffentlicht in:Journal of antimicrobial chemotherapy 2023-04, Vol.78 (4), p.1111-1116
Hauptverfasser: Cuzin, Lise, Flandre, Philippe, Allavena, Clotilde, Palich, Romain, Duvivier, Claudine, Becker, Agathe, Laroche, Hélène, Pugliese, Pascal, Cabie, André
Format: Artikel
Sprache:eng
Schlagworte:
Anti-HIV Agents - therapeutic use
HIV Infections
Human health and pathology
Humans
Immunology
Infectious diseases
Integrases
Life Sciences
Proportional Hazards Models
Treatment Failure
Viral Load
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Zusammenfassung:Abstract Objectives To analyse the occurrence of virological failure (VF) in patients starting ART with an integrase strand transfer inhibitor (INSTI)-based regimen in recent years, in relation with previous episodes of low-level viral load (LLVL). Patients and methods Patients starting a first ART between 1 January 2015 and 31 December 2020 based on two NRTIs and one INSTI were included if after virological control (two measures of VL 
ISSN:0305-7453
1460-2091
DOI:10.1093/jac/dkad056