Resolution of DL-2-aminosuberic acid via protease-catalyzed ester hydrolysis

Resolution of DL-2-aminosuberic acid via protease-catalyzed ester hydrolysis

Papain-catalyzed regioselective cleavage of alpha-methyl ester in Z-DL-Asu(OMe)-OMe leads to Z-L-Asu(OMe)-OH and Z-D-Asu(OMe)-OMe. Subsequent saponifications yield Z-L-Asu-OH and Z-D-Asu-OH. The enzymatic alpha-ester hydrolysis was also achieved by subtilisin BPN' in organic solvent with low wa...

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Veröffentlicht in:Amino acids 1998-01, Vol.15 (4), p.389-392
Hauptverfasser: Rivard, M, Malon, P, Cerovský, V
Format: Artikel
Sprache:eng
Schlagworte:
Amino acids
Amino Acids - chemistry
Amino Acids, Dicarboxylic - analysis
Caprylates
Chemical Sciences
Cleavage
Dicarboxylic Acids - chemistry
Esters
Hydrolysis
Moisture content
Papain - chemistry
Solvents
Subtilisins - chemistry
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Zusammenfassung:Papain-catalyzed regioselective cleavage of alpha-methyl ester in Z-DL-Asu(OMe)-OMe leads to Z-L-Asu(OMe)-OH and Z-D-Asu(OMe)-OMe. Subsequent saponifications yield Z-L-Asu-OH and Z-D-Asu-OH. The enzymatic alpha-ester hydrolysis was also achieved by subtilisin BPN' in organic solvent with low water content.
ISSN:0939-4451
1438-2199
DOI:10.1007/BF01320903