Safety and oncologic efficacy of percutaneous MRI-guided cryoablation of intraparenchymal renal cancers

•MR-guided cryoablation of entirely intraparenchymal renal cell cancer yields good oncological results.•Most complications of MRI-guided cryoablation of entirely intraparenchymal renal cell cancer are hemorrhages and remain minor allowing a conservative management.•The impact of MRI-guided cryoablation of entirely intraparenchymal renal cell cancer on kidney function is acceptable with a mean 16% renal function decrease and only few (3%) patients requiring dialysis after the procedure. The purpose of this study was to evaluate the safety and oncologic efficacy of percutaneous magnetic resonance imaging (MRI)-guided cryoablation of intraparenchymal renal cancer. Between February 2009 and August 2019, 31 consecutives patients with 31 entirely intraparenchymal biopsy-proven renal cancers were treated with cryoablation under MRI-guidance in our institution, and were retrospectively included. There were 20 men and 11 women with a mean age of 68.5±12.5 (SD) (range: 40–91years). Patient, tumor- and procedure-related, and follow-up data were retrospectively collected and analyzed. Local recurrence free (LRFS), metastasis free (MFS), disease free (DFS), cancer specific (CSS), and overall survivals (OS) were calculated. Primary and secondary technical efficacy rates were 94% and 100%, respectively. Median follow-up was 27months. Seven (7/31; 23%) minor complications were noted in 7 patients. Patients showed a significant decline of the estimated glomerular filtration rate (eGFR) between baseline and nadir (mean basal eGFR 65.9±22.4 [SD] mL/min/1.73m2vs. mean nadir eGFR 52.8±26.0 [SD] mL/min/1.73m2; P