Elevated LDL-cholesterol levels among lean mass hyper-responders on low-carbohydrate ketogenic diets deserve urgent clinical attention and further research

Elevated LDL-cholesterol levels among lean mass hyper-responders on low-carbohydrate ketogenic diets deserve urgent clinical attention and further research

•Lean mass hyper-responders exhibit extreme increases in LDL-c on ketogenic diets.•LDL-c increases in LMHRs are dependent on carbohydrate restriction.•Other cardiometabolic risk factors are normal to optimal in LMHRs.•A prudent clinical approach is required for managing LDL-c in LMHR patients.•Resea...

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Veröffentlicht in:Journal of clinical lipidology 2022-11, Vol.16 (6), p.765-768
Hauptverfasser: Norwitz, Nicholas G., Mindrum, Michael R., Giral, Philippe, Kontush, Anatol, Soto-Mota, Adrian, Wood, Thomas R., D'Agostino, Dominic P., Manubolu, Venkat S., Budoff, Matthew, Krauss, Ronald M.
Format: Artikel
Sprache:eng
Schlagworte:
Atherosclerotic cardiovascular disease
Attention
Carbohydrate restriction
Carbohydrates
Cholesterol
Cholesterol, HDL
Diet, Carbohydrate-Restricted
Diet, Ketogenic
HDL cholesterol
Humans
Ketogenic diet
LDL cholesterol
Lean mass hyper-responder
Life Sciences
Triglycerides
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Beschreibung
Zusammenfassung:•Lean mass hyper-responders exhibit extreme increases in LDL-c on ketogenic diets.•LDL-c increases in LMHRs are dependent on carbohydrate restriction.•Other cardiometabolic risk factors are normal to optimal in LMHRs.•A prudent clinical approach is required for managing LDL-c in LMHR patients.•Research is warranted to assess mechanisms and cardiovascular risk of this trait.
ISSN:1933-2874
1876-4789
DOI:10.1016/j.jacl.2022.10.010