Mechanical ventilation in patients with cardiogenic pulmonary edema: a sub-analysis of the LUNG SAFE study
Abstract Background Patients with acute respiratory failure caused by cardiogenic pulmonary edema (CPE) may require mechanical ventilation that can cause further lung damage. Our aim was to determine the impact of ventilatory settings on CPE mortality. Methods Patients from the LUNG SAFE cohort, a m...
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| Veröffentlicht in: | Journal of intensive care 2022-12, Vol.10 (1) |
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| creator | Amado-Rodríguez, Laura Rodríguez-Garcia, Raquel Bellani, Giacomo Pham, Tài Fan, Eddy Madotto, Fabiana Laffey, John Albaiceta, Guillermo Pesenti, Antonio Brochard, Laurent Esteban, Andres Gattinoni, Luciano van Haren, Frank Larsson, Anders Mcauley, Danielf Ranieri, Marco Rubenfeld, Gordon Taylor Thompson, B. Wrigge, Hermann Slutsky, Arthur Rios, Fernando Sottiaux, Thierry Depuydt, Pieter Lora, Fredy Azevedo, Luciano Cesar Bugedo, Guillermo Qiu, Haibo Gonzalez, Marcos Silesky, Juan Cerny, Vladimir Nielsen, Jonas Jibaja, Manuel Matamis, Dimitrios Ranero, Jorge Luis Amin, Pravin Hashemian, S. Clarkson, Kevin Kurahashi, Kiyoyasu Villagomez, Asisclo Zeggwagh, Amine Ali Heunks, Leo Laake, Jon Henrik Palo, Jose Emmanuel Do Vale Fernandes, Antero Sandesc, Dorel Arabi, Yaasen Bumbasierevic, Vesna Nin, Nicolas Lorente, Jose Piquilloud, Lise Abroug, Fekri Mcnamee, Lia Hurtado, Javier Bajwa, Ed Démpaire, Gabriel Sula, Hektor Nunci, Lordian Cani, Alma Zazu, Alan Dellera, Christian Insaurralde, Carolina Las Lomas, Sanatorio Isidro, San Alejandro, Risso Daldin, Julio Vinzio, Mauricio Fernandez, Ruben Cardonnet, Luis Bettini, Lisandro Bisso, Mariano Carboni Osman, Emilio Setten, Mariano Lovazzano, Pablo Alvarez, Javier Villar, Veronica Pozo, Norberto Grubissich, Nicolas Plotnikow, Gustavo Vasquez, Daniela Ilutovich, Santiago Tiribelli, Norberto Chena, Ariel Pellegrini, Carlos Saenz, María Estenssoro, Elisa Brizuela, Matias Gianinetto, Hernan Gomez, Pablo Cerrato, Valeria Bezzi, Marco Borello, Silvina Loiacono, Flavia Fernandez, Adriana Knowles, Serena Reynolds, Claire Inskip, Deborah Miller, Jennene Kong, Jing Whitehead, Christina Bihari, Shailesh |
| description | Abstract Background Patients with acute respiratory failure caused by cardiogenic pulmonary edema (CPE) may require mechanical ventilation that can cause further lung damage. Our aim was to determine the impact of ventilatory settings on CPE mortality. Methods Patients from the LUNG SAFE cohort, a multicenter prospective cohort study of patients undergoing mechanical ventilation, were studied. Relationships between ventilatory parameters and outcomes (ICU discharge/hospital mortality) were assessed using latent mixture analysis and a marginal structural model. Results From 4499 patients, 391 meeting CPE criteria (median age 70 [interquartile range 59–78], 40% female) were included. ICU and hospital mortality were 34% and 40%, respectively. ICU survivors were younger (67 [57–77] vs 74 [64–80] years, p |
| doi_str_mv | 10.1186/s40560-022-00648-x |
| format | Article |
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Rodríguez-Garcia, Raquel ; Bellani, Giacomo ; Pham, Tài ; Fan, Eddy ; Madotto, Fabiana ; Laffey, John ; Albaiceta, Guillermo ; Pesenti, Antonio ; Brochard, Laurent ; Esteban, Andres ; Gattinoni, Luciano ; van Haren, Frank ; Larsson, Anders ; Mcauley, Danielf ; Ranieri, Marco ; Rubenfeld, Gordon ; Taylor Thompson, B. ; Wrigge, Hermann ; Slutsky, Arthur ; Rios, Fernando ; Sottiaux, Thierry ; Depuydt, Pieter ; Lora, Fredy ; Azevedo, Luciano Cesar ; Bugedo, Guillermo ; Qiu, Haibo ; Gonzalez, Marcos ; Silesky, Juan ; Cerny, Vladimir ; Nielsen, Jonas ; Jibaja, Manuel ; Matamis, Dimitrios ; Ranero, Jorge Luis ; Amin, Pravin ; Hashemian, S. ; Clarkson, Kevin ; Kurahashi, Kiyoyasu ; Villagomez, Asisclo ; Zeggwagh, Amine Ali ; Heunks, Leo ; Laake, Jon Henrik ; Palo, Jose Emmanuel ; Do Vale Fernandes, Antero ; Sandesc, Dorel ; Arabi, Yaasen ; Bumbasierevic, Vesna ; Nin, Nicolas ; Lorente, Jose ; Piquilloud, Lise ; Abroug, Fekri ; Mcnamee, Lia ; Hurtado, Javier ; Bajwa, Ed ; Démpaire, Gabriel ; Sula, Hektor ; Nunci, Lordian ; Cani, Alma ; Zazu, Alan ; Dellera, Christian ; Insaurralde, Carolina ; Las Lomas, Sanatorio ; Isidro, San ; Alejandro, Risso ; Daldin, Julio ; Vinzio, Mauricio ; Fernandez, Ruben ; Cardonnet, Luis ; Bettini, Lisandro ; Bisso, Mariano Carboni ; Osman, Emilio ; Setten, Mariano ; Lovazzano, Pablo ; Alvarez, Javier ; Villar, Veronica ; Pozo, Norberto ; Grubissich, Nicolas ; Plotnikow, Gustavo ; Vasquez, Daniela ; Ilutovich, Santiago ; Tiribelli, Norberto ; Chena, Ariel ; Pellegrini, Carlos ; Saenz, María ; Estenssoro, Elisa ; Brizuela, Matias ; Gianinetto, Hernan ; Gomez, Pablo ; Cerrato, Valeria ; Bezzi, Marco ; Borello, Silvina ; Loiacono, Flavia ; Fernandez, Adriana ; Knowles, Serena ; Reynolds, Claire ; Inskip, Deborah ; Miller, Jennene ; Kong, Jing ; Whitehead, Christina ; Bihari, Shailesh</creator><creatorcontrib>Amado-Rodríguez, Laura ; Rodríguez-Garcia, Raquel ; Bellani, Giacomo ; Pham, Tài ; Fan, Eddy ; Madotto, Fabiana ; Laffey, John ; Albaiceta, Guillermo ; Pesenti, Antonio ; Brochard, Laurent ; Esteban, Andres ; Gattinoni, Luciano ; van Haren, Frank ; Larsson, Anders ; Mcauley, Danielf ; Ranieri, Marco ; Rubenfeld, Gordon ; Taylor Thompson, B. ; Wrigge, Hermann ; Slutsky, Arthur ; Rios, Fernando ; Sottiaux, Thierry ; Depuydt, Pieter ; Lora, Fredy ; Azevedo, Luciano Cesar ; Bugedo, Guillermo ; Qiu, Haibo ; Gonzalez, Marcos ; Silesky, Juan ; Cerny, Vladimir ; Nielsen, Jonas ; Jibaja, Manuel ; Matamis, Dimitrios ; Ranero, Jorge Luis ; Amin, Pravin ; Hashemian, S. ; Clarkson, Kevin ; Kurahashi, Kiyoyasu ; Villagomez, Asisclo ; Zeggwagh, Amine Ali ; Heunks, Leo ; Laake, Jon Henrik ; Palo, Jose Emmanuel ; Do Vale Fernandes, Antero ; Sandesc, Dorel ; Arabi, Yaasen ; Bumbasierevic, Vesna ; Nin, Nicolas ; Lorente, Jose ; Piquilloud, Lise ; Abroug, Fekri ; Mcnamee, Lia ; Hurtado, Javier ; Bajwa, Ed ; Démpaire, Gabriel ; Sula, Hektor ; Nunci, Lordian ; Cani, Alma ; Zazu, Alan ; Dellera, Christian ; Insaurralde, Carolina ; Las Lomas, Sanatorio ; Isidro, San ; Alejandro, Risso ; Daldin, Julio ; Vinzio, Mauricio ; Fernandez, Ruben ; Cardonnet, Luis ; Bettini, Lisandro ; Bisso, Mariano Carboni ; Osman, Emilio ; Setten, Mariano ; Lovazzano, Pablo ; Alvarez, Javier ; Villar, Veronica ; Pozo, Norberto ; Grubissich, Nicolas ; Plotnikow, Gustavo ; Vasquez, Daniela ; Ilutovich, Santiago ; Tiribelli, Norberto ; Chena, Ariel ; Pellegrini, Carlos ; Saenz, María ; Estenssoro, Elisa ; Brizuela, Matias ; Gianinetto, Hernan ; Gomez, Pablo ; Cerrato, Valeria ; Bezzi, Marco ; Borello, Silvina ; Loiacono, Flavia ; Fernandez, Adriana ; Knowles, Serena ; Reynolds, Claire ; Inskip, Deborah ; Miller, Jennene ; Kong, Jing ; Whitehead, Christina ; Bihari, Shailesh</creatorcontrib><description>Abstract Background Patients with acute respiratory failure caused by cardiogenic pulmonary edema (CPE) may require mechanical ventilation that can cause further lung damage. Our aim was to determine the impact of ventilatory settings on CPE mortality. Methods Patients from the LUNG SAFE cohort, a multicenter prospective cohort study of patients undergoing mechanical ventilation, were studied. Relationships between ventilatory parameters and outcomes (ICU discharge/hospital mortality) were assessed using latent mixture analysis and a marginal structural model. Results From 4499 patients, 391 meeting CPE criteria (median age 70 [interquartile range 59–78], 40% female) were included. ICU and hospital mortality were 34% and 40%, respectively. ICU survivors were younger (67 [57–77] vs 74 [64–80] years, p < 0.001) and had lower driving (12 [8–16] vs 15 [11–17] cmH 2 O, p < 0.001), plateau (20 [15–23] vs 22 [19–26] cmH 2 O, p < 0.001) and peak (21 [17–27] vs 26 [20–32] cmH 2 O, p < 0.001) pressures. Latent mixture analysis of patients receiving invasive mechanical ventilation on ICU day 1 revealed a subgroup ventilated with high pressures with lower probability of being discharged alive from the ICU (hazard ratio [HR] 0.79 [95% confidence interval 0.60–1.05], p = 0.103) and increased hospital mortality (HR 1.65 [1.16–2.36], p = 0.005). In a marginal structural model, driving pressures in the first week (HR 1.12 [1.06–1.18], p < 0.001) and tidal volume after day 7 (HR 0.69 [0.52–0.93], p = 0.015) were related to survival. Conclusions Higher airway pressures in invasively ventilated patients with CPE are related to mortality. These patients may be exposed to an increased risk of ventilator-induced lung injury. Trial registration Clinicaltrials.gov NCT02010073</description><identifier>ISSN: 2052-0492</identifier><identifier>EISSN: 2052-0492</identifier><identifier>DOI: 10.1186/s40560-022-00648-x</identifier><language>eng</language><publisher>BioMed Central</publisher><subject>Life Sciences</subject><ispartof>Journal of intensive care, 2022-12, Vol.10 (1)</ispartof><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><orcidid>0000-0002-2681-8260 ; 0000-0002-4833-4320 ; 0000-0002-9276-3253 ; 0000-0002-4373-0711 ; 0000-0003-4036-6245 ; 0000-0002-5644-3412 ; 0000-0002-6030-3957 ; 0000-0002-8198-1239 ; 0000-0002-1112-1807 ; 0000-0002-7481-5101 ; 0000-0002-9276-3253 ; 0000-0002-4373-0711</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,776,780,860,881,27901,27902</link.rule.ids><backlink>$$Uhttps://hal.science/hal-03995504$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Amado-Rodríguez, Laura</creatorcontrib><creatorcontrib>Rodríguez-Garcia, Raquel</creatorcontrib><creatorcontrib>Bellani, Giacomo</creatorcontrib><creatorcontrib>Pham, Tài</creatorcontrib><creatorcontrib>Fan, Eddy</creatorcontrib><creatorcontrib>Madotto, Fabiana</creatorcontrib><creatorcontrib>Laffey, John</creatorcontrib><creatorcontrib>Albaiceta, Guillermo</creatorcontrib><creatorcontrib>Pesenti, Antonio</creatorcontrib><creatorcontrib>Brochard, Laurent</creatorcontrib><creatorcontrib>Esteban, Andres</creatorcontrib><creatorcontrib>Gattinoni, Luciano</creatorcontrib><creatorcontrib>van Haren, Frank</creatorcontrib><creatorcontrib>Larsson, Anders</creatorcontrib><creatorcontrib>Mcauley, Danielf</creatorcontrib><creatorcontrib>Ranieri, Marco</creatorcontrib><creatorcontrib>Rubenfeld, Gordon</creatorcontrib><creatorcontrib>Taylor Thompson, B.</creatorcontrib><creatorcontrib>Wrigge, Hermann</creatorcontrib><creatorcontrib>Slutsky, Arthur</creatorcontrib><creatorcontrib>Rios, Fernando</creatorcontrib><creatorcontrib>Sottiaux, Thierry</creatorcontrib><creatorcontrib>Depuydt, Pieter</creatorcontrib><creatorcontrib>Lora, Fredy</creatorcontrib><creatorcontrib>Azevedo, Luciano Cesar</creatorcontrib><creatorcontrib>Bugedo, Guillermo</creatorcontrib><creatorcontrib>Qiu, Haibo</creatorcontrib><creatorcontrib>Gonzalez, Marcos</creatorcontrib><creatorcontrib>Silesky, Juan</creatorcontrib><creatorcontrib>Cerny, Vladimir</creatorcontrib><creatorcontrib>Nielsen, Jonas</creatorcontrib><creatorcontrib>Jibaja, Manuel</creatorcontrib><creatorcontrib>Matamis, Dimitrios</creatorcontrib><creatorcontrib>Ranero, Jorge Luis</creatorcontrib><creatorcontrib>Amin, Pravin</creatorcontrib><creatorcontrib>Hashemian, S.</creatorcontrib><creatorcontrib>Clarkson, Kevin</creatorcontrib><creatorcontrib>Kurahashi, Kiyoyasu</creatorcontrib><creatorcontrib>Villagomez, Asisclo</creatorcontrib><creatorcontrib>Zeggwagh, Amine Ali</creatorcontrib><creatorcontrib>Heunks, Leo</creatorcontrib><creatorcontrib>Laake, Jon Henrik</creatorcontrib><creatorcontrib>Palo, Jose Emmanuel</creatorcontrib><creatorcontrib>Do Vale Fernandes, Antero</creatorcontrib><creatorcontrib>Sandesc, Dorel</creatorcontrib><creatorcontrib>Arabi, Yaasen</creatorcontrib><creatorcontrib>Bumbasierevic, Vesna</creatorcontrib><creatorcontrib>Nin, Nicolas</creatorcontrib><creatorcontrib>Lorente, Jose</creatorcontrib><creatorcontrib>Piquilloud, Lise</creatorcontrib><creatorcontrib>Abroug, Fekri</creatorcontrib><creatorcontrib>Mcnamee, Lia</creatorcontrib><creatorcontrib>Hurtado, Javier</creatorcontrib><creatorcontrib>Bajwa, Ed</creatorcontrib><creatorcontrib>Démpaire, Gabriel</creatorcontrib><creatorcontrib>Sula, Hektor</creatorcontrib><creatorcontrib>Nunci, Lordian</creatorcontrib><creatorcontrib>Cani, Alma</creatorcontrib><creatorcontrib>Zazu, Alan</creatorcontrib><creatorcontrib>Dellera, Christian</creatorcontrib><creatorcontrib>Insaurralde, Carolina</creatorcontrib><creatorcontrib>Las Lomas, Sanatorio</creatorcontrib><creatorcontrib>Isidro, San</creatorcontrib><creatorcontrib>Alejandro, Risso</creatorcontrib><creatorcontrib>Daldin, Julio</creatorcontrib><creatorcontrib>Vinzio, Mauricio</creatorcontrib><creatorcontrib>Fernandez, Ruben</creatorcontrib><creatorcontrib>Cardonnet, Luis</creatorcontrib><creatorcontrib>Bettini, Lisandro</creatorcontrib><creatorcontrib>Bisso, Mariano Carboni</creatorcontrib><creatorcontrib>Osman, Emilio</creatorcontrib><creatorcontrib>Setten, Mariano</creatorcontrib><creatorcontrib>Lovazzano, Pablo</creatorcontrib><creatorcontrib>Alvarez, Javier</creatorcontrib><creatorcontrib>Villar, Veronica</creatorcontrib><creatorcontrib>Pozo, Norberto</creatorcontrib><creatorcontrib>Grubissich, Nicolas</creatorcontrib><creatorcontrib>Plotnikow, Gustavo</creatorcontrib><creatorcontrib>Vasquez, Daniela</creatorcontrib><creatorcontrib>Ilutovich, Santiago</creatorcontrib><creatorcontrib>Tiribelli, Norberto</creatorcontrib><creatorcontrib>Chena, Ariel</creatorcontrib><creatorcontrib>Pellegrini, Carlos</creatorcontrib><creatorcontrib>Saenz, María</creatorcontrib><creatorcontrib>Estenssoro, Elisa</creatorcontrib><creatorcontrib>Brizuela, Matias</creatorcontrib><creatorcontrib>Gianinetto, Hernan</creatorcontrib><creatorcontrib>Gomez, Pablo</creatorcontrib><creatorcontrib>Cerrato, Valeria</creatorcontrib><creatorcontrib>Bezzi, Marco</creatorcontrib><creatorcontrib>Borello, Silvina</creatorcontrib><creatorcontrib>Loiacono, Flavia</creatorcontrib><creatorcontrib>Fernandez, Adriana</creatorcontrib><creatorcontrib>Knowles, Serena</creatorcontrib><creatorcontrib>Reynolds, Claire</creatorcontrib><creatorcontrib>Inskip, Deborah</creatorcontrib><creatorcontrib>Miller, Jennene</creatorcontrib><creatorcontrib>Kong, Jing</creatorcontrib><creatorcontrib>Whitehead, Christina</creatorcontrib><creatorcontrib>Bihari, Shailesh</creatorcontrib><title>Mechanical ventilation in patients with cardiogenic pulmonary edema: a sub-analysis of the LUNG SAFE study</title><title>Journal of intensive care</title><description>Abstract Background Patients with acute respiratory failure caused by cardiogenic pulmonary edema (CPE) may require mechanical ventilation that can cause further lung damage. Our aim was to determine the impact of ventilatory settings on CPE mortality. Methods Patients from the LUNG SAFE cohort, a multicenter prospective cohort study of patients undergoing mechanical ventilation, were studied. Relationships between ventilatory parameters and outcomes (ICU discharge/hospital mortality) were assessed using latent mixture analysis and a marginal structural model. Results From 4499 patients, 391 meeting CPE criteria (median age 70 [interquartile range 59–78], 40% female) were included. ICU and hospital mortality were 34% and 40%, respectively. ICU survivors were younger (67 [57–77] vs 74 [64–80] years, p < 0.001) and had lower driving (12 [8–16] vs 15 [11–17] cmH 2 O, p < 0.001), plateau (20 [15–23] vs 22 [19–26] cmH 2 O, p < 0.001) and peak (21 [17–27] vs 26 [20–32] cmH 2 O, p < 0.001) pressures. Latent mixture analysis of patients receiving invasive mechanical ventilation on ICU day 1 revealed a subgroup ventilated with high pressures with lower probability of being discharged alive from the ICU (hazard ratio [HR] 0.79 [95% confidence interval 0.60–1.05], p = 0.103) and increased hospital mortality (HR 1.65 [1.16–2.36], p = 0.005). In a marginal structural model, driving pressures in the first week (HR 1.12 [1.06–1.18], p < 0.001) and tidal volume after day 7 (HR 0.69 [0.52–0.93], p = 0.015) were related to survival. Conclusions Higher airway pressures in invasively ventilated patients with CPE are related to mortality. These patients may be exposed to an increased risk of ventilator-induced lung injury. 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Deborah</creator><creator>Miller, Jennene</creator><creator>Kong, Jing</creator><creator>Whitehead, Christina</creator><creator>Bihari, Shailesh</creator><general>BioMed Central</general><scope>1XC</scope><orcidid>https://orcid.org/0000-0002-2681-8260</orcidid><orcidid>https://orcid.org/0000-0002-4833-4320</orcidid><orcidid>https://orcid.org/0000-0002-9276-3253</orcidid><orcidid>https://orcid.org/0000-0002-4373-0711</orcidid><orcidid>https://orcid.org/0000-0003-4036-6245</orcidid><orcidid>https://orcid.org/0000-0002-5644-3412</orcidid><orcidid>https://orcid.org/0000-0002-6030-3957</orcidid><orcidid>https://orcid.org/0000-0002-8198-1239</orcidid><orcidid>https://orcid.org/0000-0002-1112-1807</orcidid><orcidid>https://orcid.org/0000-0002-7481-5101</orcidid><orcidid>https://orcid.org/0000-0002-9276-3253</orcidid><orcidid>https://orcid.org/0000-0002-4373-0711</orcidid></search><sort><creationdate>202212</creationdate><title>Mechanical ventilation in patients with cardiogenic pulmonary edema: a sub-analysis of the LUNG SAFE study</title><author>Amado-Rodríguez, Laura ; Rodríguez-Garcia, Raquel ; Bellani, Giacomo ; Pham, Tài ; Fan, Eddy ; Madotto, Fabiana ; Laffey, John ; Albaiceta, Guillermo ; Pesenti, Antonio ; Brochard, Laurent ; Esteban, Andres ; Gattinoni, Luciano ; van Haren, Frank ; Larsson, Anders ; Mcauley, Danielf ; Ranieri, Marco ; Rubenfeld, Gordon ; Taylor Thompson, B. ; Wrigge, Hermann ; Slutsky, Arthur ; Rios, Fernando ; Sottiaux, Thierry ; Depuydt, Pieter ; Lora, Fredy ; Azevedo, Luciano Cesar ; Bugedo, Guillermo ; Qiu, Haibo ; Gonzalez, Marcos ; Silesky, Juan ; Cerny, Vladimir ; Nielsen, Jonas ; Jibaja, Manuel ; Matamis, Dimitrios ; Ranero, Jorge Luis ; Amin, Pravin ; Hashemian, S. ; Clarkson, Kevin ; Kurahashi, Kiyoyasu ; Villagomez, Asisclo ; Zeggwagh, Amine Ali ; Heunks, Leo ; Laake, Jon Henrik ; Palo, Jose Emmanuel ; Do Vale Fernandes, Antero ; Sandesc, Dorel ; Arabi, Yaasen ; Bumbasierevic, Vesna ; Nin, Nicolas ; Lorente, Jose ; Piquilloud, Lise ; Abroug, Fekri ; Mcnamee, Lia ; Hurtado, Javier ; Bajwa, Ed ; Démpaire, Gabriel ; Sula, Hektor ; Nunci, Lordian ; Cani, Alma ; Zazu, Alan ; Dellera, Christian ; Insaurralde, Carolina ; Las Lomas, Sanatorio ; Isidro, San ; Alejandro, Risso ; Daldin, Julio ; Vinzio, Mauricio ; Fernandez, Ruben ; Cardonnet, Luis ; Bettini, Lisandro ; Bisso, Mariano Carboni ; Osman, Emilio ; Setten, Mariano ; Lovazzano, Pablo ; Alvarez, Javier ; Villar, Veronica ; Pozo, Norberto ; Grubissich, Nicolas ; Plotnikow, Gustavo ; Vasquez, Daniela ; Ilutovich, Santiago ; Tiribelli, Norberto ; Chena, Ariel ; Pellegrini, Carlos ; Saenz, María ; Estenssoro, Elisa ; Brizuela, Matias ; Gianinetto, Hernan ; Gomez, Pablo ; Cerrato, Valeria ; Bezzi, Marco ; Borello, Silvina ; Loiacono, Flavia ; Fernandez, Adriana ; Knowles, Serena ; Reynolds, Claire ; Inskip, Deborah ; Miller, Jennene ; Kong, Jing ; Whitehead, Christina ; Bihari, Shailesh</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-hal_primary_oai_HAL_hal_03995504v13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Life Sciences</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Amado-Rodríguez, Laura</creatorcontrib><creatorcontrib>Rodríguez-Garcia, Raquel</creatorcontrib><creatorcontrib>Bellani, Giacomo</creatorcontrib><creatorcontrib>Pham, Tài</creatorcontrib><creatorcontrib>Fan, Eddy</creatorcontrib><creatorcontrib>Madotto, Fabiana</creatorcontrib><creatorcontrib>Laffey, John</creatorcontrib><creatorcontrib>Albaiceta, Guillermo</creatorcontrib><creatorcontrib>Pesenti, Antonio</creatorcontrib><creatorcontrib>Brochard, Laurent</creatorcontrib><creatorcontrib>Esteban, Andres</creatorcontrib><creatorcontrib>Gattinoni, Luciano</creatorcontrib><creatorcontrib>van Haren, Frank</creatorcontrib><creatorcontrib>Larsson, Anders</creatorcontrib><creatorcontrib>Mcauley, Danielf</creatorcontrib><creatorcontrib>Ranieri, Marco</creatorcontrib><creatorcontrib>Rubenfeld, Gordon</creatorcontrib><creatorcontrib>Taylor Thompson, B.</creatorcontrib><creatorcontrib>Wrigge, Hermann</creatorcontrib><creatorcontrib>Slutsky, Arthur</creatorcontrib><creatorcontrib>Rios, Fernando</creatorcontrib><creatorcontrib>Sottiaux, Thierry</creatorcontrib><creatorcontrib>Depuydt, Pieter</creatorcontrib><creatorcontrib>Lora, Fredy</creatorcontrib><creatorcontrib>Azevedo, Luciano Cesar</creatorcontrib><creatorcontrib>Bugedo, Guillermo</creatorcontrib><creatorcontrib>Qiu, Haibo</creatorcontrib><creatorcontrib>Gonzalez, Marcos</creatorcontrib><creatorcontrib>Silesky, Juan</creatorcontrib><creatorcontrib>Cerny, Vladimir</creatorcontrib><creatorcontrib>Nielsen, Jonas</creatorcontrib><creatorcontrib>Jibaja, Manuel</creatorcontrib><creatorcontrib>Matamis, Dimitrios</creatorcontrib><creatorcontrib>Ranero, Jorge Luis</creatorcontrib><creatorcontrib>Amin, Pravin</creatorcontrib><creatorcontrib>Hashemian, S.</creatorcontrib><creatorcontrib>Clarkson, Kevin</creatorcontrib><creatorcontrib>Kurahashi, Kiyoyasu</creatorcontrib><creatorcontrib>Villagomez, Asisclo</creatorcontrib><creatorcontrib>Zeggwagh, Amine Ali</creatorcontrib><creatorcontrib>Heunks, Leo</creatorcontrib><creatorcontrib>Laake, Jon Henrik</creatorcontrib><creatorcontrib>Palo, Jose Emmanuel</creatorcontrib><creatorcontrib>Do Vale Fernandes, Antero</creatorcontrib><creatorcontrib>Sandesc, Dorel</creatorcontrib><creatorcontrib>Arabi, Yaasen</creatorcontrib><creatorcontrib>Bumbasierevic, Vesna</creatorcontrib><creatorcontrib>Nin, Nicolas</creatorcontrib><creatorcontrib>Lorente, Jose</creatorcontrib><creatorcontrib>Piquilloud, Lise</creatorcontrib><creatorcontrib>Abroug, Fekri</creatorcontrib><creatorcontrib>Mcnamee, Lia</creatorcontrib><creatorcontrib>Hurtado, Javier</creatorcontrib><creatorcontrib>Bajwa, Ed</creatorcontrib><creatorcontrib>Démpaire, Gabriel</creatorcontrib><creatorcontrib>Sula, Hektor</creatorcontrib><creatorcontrib>Nunci, Lordian</creatorcontrib><creatorcontrib>Cani, Alma</creatorcontrib><creatorcontrib>Zazu, Alan</creatorcontrib><creatorcontrib>Dellera, Christian</creatorcontrib><creatorcontrib>Insaurralde, Carolina</creatorcontrib><creatorcontrib>Las Lomas, Sanatorio</creatorcontrib><creatorcontrib>Isidro, San</creatorcontrib><creatorcontrib>Alejandro, Risso</creatorcontrib><creatorcontrib>Daldin, Julio</creatorcontrib><creatorcontrib>Vinzio, Mauricio</creatorcontrib><creatorcontrib>Fernandez, Ruben</creatorcontrib><creatorcontrib>Cardonnet, Luis</creatorcontrib><creatorcontrib>Bettini, Lisandro</creatorcontrib><creatorcontrib>Bisso, Mariano Carboni</creatorcontrib><creatorcontrib>Osman, Emilio</creatorcontrib><creatorcontrib>Setten, Mariano</creatorcontrib><creatorcontrib>Lovazzano, Pablo</creatorcontrib><creatorcontrib>Alvarez, Javier</creatorcontrib><creatorcontrib>Villar, Veronica</creatorcontrib><creatorcontrib>Pozo, Norberto</creatorcontrib><creatorcontrib>Grubissich, Nicolas</creatorcontrib><creatorcontrib>Plotnikow, Gustavo</creatorcontrib><creatorcontrib>Vasquez, Daniela</creatorcontrib><creatorcontrib>Ilutovich, Santiago</creatorcontrib><creatorcontrib>Tiribelli, Norberto</creatorcontrib><creatorcontrib>Chena, Ariel</creatorcontrib><creatorcontrib>Pellegrini, Carlos</creatorcontrib><creatorcontrib>Saenz, María</creatorcontrib><creatorcontrib>Estenssoro, Elisa</creatorcontrib><creatorcontrib>Brizuela, Matias</creatorcontrib><creatorcontrib>Gianinetto, Hernan</creatorcontrib><creatorcontrib>Gomez, Pablo</creatorcontrib><creatorcontrib>Cerrato, Valeria</creatorcontrib><creatorcontrib>Bezzi, Marco</creatorcontrib><creatorcontrib>Borello, Silvina</creatorcontrib><creatorcontrib>Loiacono, Flavia</creatorcontrib><creatorcontrib>Fernandez, Adriana</creatorcontrib><creatorcontrib>Knowles, Serena</creatorcontrib><creatorcontrib>Reynolds, Claire</creatorcontrib><creatorcontrib>Inskip, Deborah</creatorcontrib><creatorcontrib>Miller, Jennene</creatorcontrib><creatorcontrib>Kong, Jing</creatorcontrib><creatorcontrib>Whitehead, Christina</creatorcontrib><creatorcontrib>Bihari, Shailesh</creatorcontrib><collection>Hyper Article en Ligne (HAL)</collection><jtitle>Journal of intensive care</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Amado-Rodríguez, Laura</au><au>Rodríguez-Garcia, Raquel</au><au>Bellani, Giacomo</au><au>Pham, Tài</au><au>Fan, Eddy</au><au>Madotto, Fabiana</au><au>Laffey, John</au><au>Albaiceta, Guillermo</au><au>Pesenti, Antonio</au><au>Brochard, Laurent</au><au>Esteban, Andres</au><au>Gattinoni, Luciano</au><au>van Haren, Frank</au><au>Larsson, Anders</au><au>Mcauley, Danielf</au><au>Ranieri, Marco</au><au>Rubenfeld, Gordon</au><au>Taylor Thompson, B.</au><au>Wrigge, Hermann</au><au>Slutsky, Arthur</au><au>Rios, Fernando</au><au>Sottiaux, Thierry</au><au>Depuydt, Pieter</au><au>Lora, Fredy</au><au>Azevedo, Luciano Cesar</au><au>Bugedo, Guillermo</au><au>Qiu, Haibo</au><au>Gonzalez, Marcos</au><au>Silesky, Juan</au><au>Cerny, Vladimir</au><au>Nielsen, Jonas</au><au>Jibaja, Manuel</au><au>Matamis, Dimitrios</au><au>Ranero, Jorge Luis</au><au>Amin, Pravin</au><au>Hashemian, S.</au><au>Clarkson, Kevin</au><au>Kurahashi, Kiyoyasu</au><au>Villagomez, Asisclo</au><au>Zeggwagh, Amine Ali</au><au>Heunks, Leo</au><au>Laake, Jon Henrik</au><au>Palo, Jose Emmanuel</au><au>Do Vale Fernandes, Antero</au><au>Sandesc, Dorel</au><au>Arabi, Yaasen</au><au>Bumbasierevic, Vesna</au><au>Nin, Nicolas</au><au>Lorente, Jose</au><au>Piquilloud, Lise</au><au>Abroug, Fekri</au><au>Mcnamee, Lia</au><au>Hurtado, Javier</au><au>Bajwa, Ed</au><au>Démpaire, Gabriel</au><au>Sula, Hektor</au><au>Nunci, Lordian</au><au>Cani, Alma</au><au>Zazu, Alan</au><au>Dellera, Christian</au><au>Insaurralde, Carolina</au><au>Las Lomas, Sanatorio</au><au>Isidro, San</au><au>Alejandro, Risso</au><au>Daldin, Julio</au><au>Vinzio, Mauricio</au><au>Fernandez, Ruben</au><au>Cardonnet, Luis</au><au>Bettini, Lisandro</au><au>Bisso, Mariano Carboni</au><au>Osman, Emilio</au><au>Setten, Mariano</au><au>Lovazzano, Pablo</au><au>Alvarez, Javier</au><au>Villar, Veronica</au><au>Pozo, Norberto</au><au>Grubissich, Nicolas</au><au>Plotnikow, Gustavo</au><au>Vasquez, Daniela</au><au>Ilutovich, Santiago</au><au>Tiribelli, Norberto</au><au>Chena, Ariel</au><au>Pellegrini, Carlos</au><au>Saenz, María</au><au>Estenssoro, Elisa</au><au>Brizuela, Matias</au><au>Gianinetto, Hernan</au><au>Gomez, Pablo</au><au>Cerrato, Valeria</au><au>Bezzi, Marco</au><au>Borello, Silvina</au><au>Loiacono, Flavia</au><au>Fernandez, Adriana</au><au>Knowles, Serena</au><au>Reynolds, Claire</au><au>Inskip, Deborah</au><au>Miller, Jennene</au><au>Kong, Jing</au><au>Whitehead, Christina</au><au>Bihari, Shailesh</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Mechanical ventilation in patients with cardiogenic pulmonary edema: a sub-analysis of the LUNG SAFE study</atitle><jtitle>Journal of intensive care</jtitle><date>2022-12</date><risdate>2022</risdate><volume>10</volume><issue>1</issue><issn>2052-0492</issn><eissn>2052-0492</eissn><abstract>Abstract Background Patients with acute respiratory failure caused by cardiogenic pulmonary edema (CPE) may require mechanical ventilation that can cause further lung damage. Our aim was to determine the impact of ventilatory settings on CPE mortality. Methods Patients from the LUNG SAFE cohort, a multicenter prospective cohort study of patients undergoing mechanical ventilation, were studied. Relationships between ventilatory parameters and outcomes (ICU discharge/hospital mortality) were assessed using latent mixture analysis and a marginal structural model. Results From 4499 patients, 391 meeting CPE criteria (median age 70 [interquartile range 59–78], 40% female) were included. ICU and hospital mortality were 34% and 40%, respectively. ICU survivors were younger (67 [57–77] vs 74 [64–80] years, p < 0.001) and had lower driving (12 [8–16] vs 15 [11–17] cmH 2 O, p < 0.001), plateau (20 [15–23] vs 22 [19–26] cmH 2 O, p < 0.001) and peak (21 [17–27] vs 26 [20–32] cmH 2 O, p < 0.001) pressures. Latent mixture analysis of patients receiving invasive mechanical ventilation on ICU day 1 revealed a subgroup ventilated with high pressures with lower probability of being discharged alive from the ICU (hazard ratio [HR] 0.79 [95% confidence interval 0.60–1.05], p = 0.103) and increased hospital mortality (HR 1.65 [1.16–2.36], p = 0.005). In a marginal structural model, driving pressures in the first week (HR 1.12 [1.06–1.18], p < 0.001) and tidal volume after day 7 (HR 0.69 [0.52–0.93], p = 0.015) were related to survival. Conclusions Higher airway pressures in invasively ventilated patients with CPE are related to mortality. These patients may be exposed to an increased risk of ventilator-induced lung injury. Trial registration Clinicaltrials.gov NCT02010073</abstract><pub>BioMed Central</pub><doi>10.1186/s40560-022-00648-x</doi><orcidid>https://orcid.org/0000-0002-2681-8260</orcidid><orcidid>https://orcid.org/0000-0002-4833-4320</orcidid><orcidid>https://orcid.org/0000-0002-9276-3253</orcidid><orcidid>https://orcid.org/0000-0002-4373-0711</orcidid><orcidid>https://orcid.org/0000-0003-4036-6245</orcidid><orcidid>https://orcid.org/0000-0002-5644-3412</orcidid><orcidid>https://orcid.org/0000-0002-6030-3957</orcidid><orcidid>https://orcid.org/0000-0002-8198-1239</orcidid><orcidid>https://orcid.org/0000-0002-1112-1807</orcidid><orcidid>https://orcid.org/0000-0002-7481-5101</orcidid><orcidid>https://orcid.org/0000-0002-9276-3253</orcidid><orcidid>https://orcid.org/0000-0002-4373-0711</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 2052-0492 |
| ispartof | Journal of intensive care, 2022-12, Vol.10 (1) |
| issn | 2052-0492 2052-0492 |
| language | eng |
| recordid | cdi_hal_primary_oai_HAL_hal_03995504v1 |
| source | DOAJ Directory of Open Access Journals; SpringerLink Journals; EZB-FREE-00999 freely available EZB journals; PubMed Central; PubMed Central Open Access; Springer Nature OA Free Journals |
| subjects | Life Sciences |
| title | Mechanical ventilation in patients with cardiogenic pulmonary edema: a sub-analysis of the LUNG SAFE study |
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