Highly inert Cu(ii) complexes of C-aryl bifunctional cyclam-picolinates with remarkable Cu-64-labelling and biodistribution

Highly inert Cu(ii) complexes of C-aryl bifunctional cyclam-picolinates with remarkable Cu-64-labelling and biodistribution

Cyclam-picolinate chelators were functionalized via click chemistry with an additional carboxyl group for subsequent bioconjugation to antibodies or for the modification of the overall charge of the corresponding Cu-64-radiocomplexes. The C-aryl functionalization strategy developed here preserves th...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Chemical communications (Cambridge, England) England), 2023, Vol.59 (7), p.888-891
Hauptverfasser: Pineau, Julie, Lima, Luis M P, Le Roy, M, Marionneau-Lambot, Séverine, Cordier, Marie, Le Saëc, Patricia, Zeevaart, Jan Rijn, Driver, Cathryn H. S., Faivre-Chauvet, Alain, Le Bris, Nathalie, Tripier, Raphaël
Format: Artikel
Sprache:eng
Schlagworte:
Chemical Sciences
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Cyclam-picolinate chelators were functionalized via click chemistry with an additional carboxyl group for subsequent bioconjugation to antibodies or for the modification of the overall charge of the corresponding Cu-64-radiocomplexes. The C-aryl functionalization strategy developed here preserves the chemical properties of the radiocomplexes whilst deeply enhancing their applications within nuclear medicine.
ISSN:1359-7345
1364-548X
DOI:10.1039/d2cc06602e