Randomized Trial of Vaccines for Zaire Ebola Virus Disease

In two randomized trials of Zaire Ebola vaccines, safety and immune responses in adults and children were assessed for three regimens with two different vaccines. All three induced immune responses lasting at least 1 year.

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Bibliographische Detailangaben
Veröffentlicht in:	The New England journal of medicine 2022-12, Vol.387 (26), p.2411-2424
Hauptverfasser:	Kieh, Mark, Richert, Laura, Beavogui, Abdoul H, Grund, Birgit, Leigh, Bailah, D'Ortenzio, Eric, Doumbia, Seydou, Lhomme, Edouard, Sow, Samba, Vatrinet, Renaud, Roy, Céline, Kennedy, Stephen B, Faye, Sylvain, Lees, Shelley, Millimouno, Niouma P, Camara, Alseny M, Samai, Mohamed, Deen, Gibrilla F, Doumbia, Moussa, Espérou, Hélène, Pierson, Jerome, Watson-Jones, Deborah, Diallo, Alpha, Wentworth, Deborah, McLean, Chelsea, Simon, Jakub, Wiedemann, Aurélie, Dighero-Kemp, Bonnie, Hensley, Lisa, Lane, H Clifford, Levy, Yves, Piot, Peter, Greenwood, Brian, Chêne, Geneviève, Neaton, James, Yazdanpanah, Yazdan
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Age groups Antibodies Antibodies, Viral Antibody response Biomedical research Child Children Clinical trials Confidence intervals Democratic Republic of the Congo Ebola Vaccines - therapeutic use Ebola virus Ebolavirus Enzyme-linked immunosorbent assay Global Health Glycoproteins Hemorrhagic Fever, Ebola - prevention & control Humans Immune response Immunization Infectious Disease Infectious Disease General Laboratories Life Sciences Placebos Safety Statistical analysis Vaccines Viral Infections Viruses
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Beschreibung
Zusammenfassung:	In two randomized trials of Zaire Ebola vaccines, safety and immune responses in adults and children were assessed for three regimens with two different vaccines. All three induced immune responses lasting at least 1 year.
ISSN:	0028-4793 1533-4406
DOI:	10.1056/NEJMoa2200072