Maintaining Antiretroviral Therapy Reduces the Risk of AIDS-Defining Events in Patients with Uncontrolled Viral Replication and Profound Immunodeficiency

Background. The benefits of continuing antiretroviral therapy are questionable in human immunodeficiency virus (HIV) type 1–infected patients with profound immunodeficiency and multiple treatment failure due to viral resistance. Methods. From the French Hospital Database on HIV, we selected 12,765 p...

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Veröffentlicht in:	Clinical infectious diseases 2008-01, Vol.46 (2), p.296-304
Hauptverfasser:	Kousignian, Isabelle, Abgrall, Sophie, Grabar, Sophie, Mahamat, Aba, Teicher, Elina, Rouveix, Elisabeth, Costagliola, Dominique
Format:	Artikel
Sprache:	eng
Schlagworte:	Acquired immune deficiency syndrome Acquired Immunodeficiency Syndrome - drug therapy Acquired Immunodeficiency Syndrome - immunology Acquired Immunodeficiency Syndrome - virology Adult AIDS Anti-Retroviral Agents - administration & dosage Antibiotics. Antiinfectious agents. Antiparasitic agents Antiretroviral drugs Antiretrovirals Antiviral agents Arts Biological and medical sciences Carts CD4 Lymphocyte Count - methods Cohort Studies Disease Progression Drug Combinations Drug therapy Female HIV HIV 1 HIV-1 - growth & development HIV-1 - physiology HIV/AIDS Human immunodeficiency virus Human viral diseases Humans Immunodeficiencies Immunodeficiencies. Immunoglobulinopathies Immunology Immunopathology Infectious diseases Life Sciences Male Medical sciences Middle Aged Pharmacology. Drug treatments Prospective Studies Risk Risk Factors Santé publique et épidémiologie T lymphocytes Viral diseases Viral diseases of the lymphoid tissue and the blood. Aids Viral Load Virology Virus Replication Viruses
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Zusammenfassung:	Background. The benefits of continuing antiretroviral therapy are questionable in human immunodeficiency virus (HIV) type 1–infected patients with profound immunodeficiency and multiple treatment failure due to viral resistance. Methods. From the French Hospital Database on HIV, we selected 12,765 patients with a CD4+ cell count
ISSN:	1058-4838 1537-6591
DOI:	10.1086/524753