Should Patients With Acute Minor Ischemic Stroke With Isolated Internal Carotid Artery Occlusion Be Thrombolysed?

Should Patients With Acute Minor Ischemic Stroke With Isolated Internal Carotid Artery Occlusion Be Thrombolysed?

BACKGROUNDWe recently reported a worrying 30% rate of early neurological deterioration (END) occurring within 24 hours following intravenous thrombolysis (IVT) in minor stroke with isolated internal carotid artery occlusion (ie, without additional intracranial occlusion), mainly due to artery-to-art...

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Veröffentlicht in:Stroke (1970) 2022-11, Vol.53 (11), p.3304-3312
Hauptverfasser: Boulenoir, Naouel, Turc, Guillaume, Ter Schiphorst, Adrien, Heldner, Mirjam R., Strambo, Davide, Laksiri, Nadia, Girard Buttaz, Isabelle, Papassin, Jérémie, Sibon, Igor, Chausson, Nicolas, Michel, Patrik, Rosso, Charlotte, Bourdain, Frédéric, Lamy, Chantal, Weisenburger-Lile, David, Agius, Pierre, Yger, Marion, Obadia, Michael, Sablot, Denis, Legris, Nicolas, Jung, Simon, Pilgram-Pastor, Sara, Henon, Hilde, Bernardaud, Lucy, Arquizan, Caroline, Baron, Jean-Claude, Seners, Pierre
Format: Artikel
Sprache:eng
Schlagworte:
Human health and pathology
Life Sciences
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Zusammenfassung:BACKGROUNDWe recently reported a worrying 30% rate of early neurological deterioration (END) occurring within 24 hours following intravenous thrombolysis (IVT) in minor stroke with isolated internal carotid artery occlusion (ie, without additional intracranial occlusion), mainly due to artery-to-artery embolism. Here, we hypothesize that in this setting IVT-as compared to no-IVT-may foster END, in particular by favoring artery-to-artery embolism from thrombus fragmentation. METHODSFrom a large multicenter retrospective database, we compared minor stroke (National Institutes of Health Stroke Scale score
ISSN:0039-2499
1524-4628
DOI:10.1161/STROKEAHA.122.039228