Intravenous Vitamin C in Adults with Sepsis in the Intensive Care Unit

In this trial of intravenous vitamin C in adult patients with sepsis, those who received a vitamin C infusion had a higher risk of death or persistent organ dysfunction at 28 days than those who received placebo.

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Bibliographische Detailangaben
Veröffentlicht in:	The New England journal of medicine 2022-06, Vol.386 (25), p.2387-2398
Hauptverfasser:	Lamontagne, François, Masse, Marie-Hélène, Menard, Julie, Sprague, Sheila, Pinto, Ruxandra, Heyland, Daren K., Cook, Deborah J, Battista, Marie-Claude, Day, Andrew G., Guyatt, Gordon H., Kanji, Salmaan, Parke, Rachael, McGuinness, Shay P., Tirupakuzhi Vijayaraghavan, Bharath-Kumar, Annane, Djillali, Cohen, Dian, Arabi, Yaseen M., Bolduc, Brigitte, Marinoff, Nicole, Rochwerg, Bram, Millen, Tina, Meade, Maureen O., Hand, Lori, Watpool, Irene, Porteous, Rebecca, Young, Paul J., D’Aragon, Frederick, Belley-Cote, Emilie P., Carbonneau, Elaine, Clarke, France, Maslove, David M., Hunt, Miranda, Chassé, Michaël, Lebrasseur, Martine, Lauzier, François, Mehta, Sangeeta, Quiroz-Martinez, Hector, Rewa, Oleksa G., Charbonney, Emmanuel, Seely, Andrew J.E., Kutsogiannis, Demetrios J., LeBlanc, Remi, Mekontso-Dessap, Armand, Mele, Tina S., Turgeon, Alexis F., Wood, Gordon, Kohli, Sandeep S., Shahin, Jason, Twardowski, Pawel, Adhikari, Neill K.J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Anaphylaxis Ascorbic acid Ascorbic Acid - adverse effects Biomarkers Body weight Clinical Medicine Consent Critical Care Critical Care General Death Emergency Medicine Emergency Medicine General Hospital-Based Clinical Medicine Humans Hypoglycemic Agents - therapeutic use Infections Infectious Disease Infectious Disease General Intensive care Intensive Care Units Intravenous administration Life Sciences Mechanical ventilation Mortality Multiple Organ Failure Placebos Pulmonary Quality of Life Sepsis Sepsis - drug therapy Severe acute respiratory syndrome coronavirus 2 Vasoconstrictor Agents - adverse effects Vitamin C Vitamins - adverse effects
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Beschreibung
Zusammenfassung:	In this trial of intravenous vitamin C in adult patients with sepsis, those who received a vitamin C infusion had a higher risk of death or persistent organ dysfunction at 28 days than those who received placebo.
ISSN:	0028-4793 1533-4406
DOI:	10.1056/NEJMoa2200644