A Comparison of Two LDL Cholesterol Targets after Ischemic Stroke

In this trial, patients with stroke or TIA and atherosclerosis who received a statin with or without ezetimibe were randomly assigned to an LDL cholesterol target of less than 70 mg per deciliter or to a target range of 90 to 110 mg per deciliter. At a median follow-up of 3.5 years, the incidence of...

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Veröffentlicht in:	The New England journal of medicine 2020-01, Vol.382 (1), p.9-19
Hauptverfasser:	Amarenco, Pierre, Kim, Jong S, Labreuche, Julien, Charles, Hugo, Abtan, Jérémie, Béjot, Yannick, Cabrejo, Lucie, Cha, Jae-Kwan, Ducrocq, Grégory, Giroud, Maurice, Guidoux, Celine, Hobeanu, Cristina, Kim, Yong-Jae, Lapergue, Bertrand, Lavallée, Philippa C, Lee, Byung-Chul, Lee, Kyung-Bok, Leys, Didier, Mahagne, Marie-Hélène, Meseguer, Elena, Nighoghossian, Norbert, Pico, Fernando, Samson, Yves, Sibon, Igor, Steg, P. Gabriel, Sung, Sang-Min, Touboul, Pierre-Jean, Touzé, Emmanuel, Varenne, Olivier, Vicaut, Éric, Yelles, Nessima, Bruckert, Eric
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Anticholesteremic Agents - adverse effects Anticholesteremic Agents - therapeutic use Arteriosclerosis Atherosclerosis - complications Atherosclerosis - drug therapy Brain Ischemia - drug therapy Cardiovascular diseases Cardiovascular Diseases - mortality Cardiovascular Diseases - prevention & control Cerebral infarction Cholesterol Cholesterol, LDL - blood Diabetes mellitus Drug Therapy, Combination Ezetimibe - therapeutic use Female Health risk assessment Hemorrhage Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use Intention to Treat Analysis Ischemia Ischemic Attack, Transient - complications Ischemic Attack, Transient - drug therapy Kaplan-Meier Estimate Life Sciences Low density lipoprotein Male Medical imaging Middle Aged Myocardial infarction Statins Stroke Stroke - blood Stroke - drug therapy Transient ischemic attack
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Zusammenfassung:	In this trial, patients with stroke or TIA and atherosclerosis who received a statin with or without ezetimibe were randomly assigned to an LDL cholesterol target of less than 70 mg per deciliter or to a target range of 90 to 110 mg per deciliter. At a median follow-up of 3.5 years, the incidence of a composite cardiovascular end point was 12% lower in the lower-target group than in the higher-target group. The incidence of cerebral hemorrhage did not differ significantly between the two groups.
ISSN:	0028-4793 1533-4406
DOI:	10.1056/NEJMoa1910355