Triacylglycerols containing branched palmitic acid ester of hydroxystearic acid (PAHSA) are present in the breast milk and hydrolyzed by carboxyl ester lipase
[Display omitted] •Effect of preterm birth (PB) or caesarean section (CS) on milk metabolome.•Colostrum levels of 5-PAHSA were negatively affected by PB and CS.•FAHFA-containing triacylglycerols are substrates of carboxyl ester lipase in milk.•5-PAHSA-containing lipids are resistant to carboxyl este...
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| Veröffentlicht in: | Food chemistry 2022-09, Vol.388, p.132983-132983, Article 132983 |
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| creator | Brejchova, Kristyna Paluchova, Veronika Brezinova, Marie Cajka, Tomas Balas, Laurence Durand, Thierry Krizova, Marcela Stranak, Zbynek Kuda, Ondrej |
| description | [Display omitted]
•Effect of preterm birth (PB) or caesarean section (CS) on milk metabolome.•Colostrum levels of 5-PAHSA were negatively affected by PB and CS.•FAHFA-containing triacylglycerols are substrates of carboxyl ester lipase in milk.•5-PAHSA-containing lipids are resistant to carboxyl ester lipase hydrolysis.
Breast milk is a complex mixture containing underexplored bioactive lipids. We performed an observational case-control study to compare the impact of delivery mode: caesarean section (CS) and vaginal birth (VB); and term (preterm and term delivery) on the levels of lipokines in human milk at different stages of lactation. Metabolomic analysis of the milk identified triacylglycerol estolides as a metabolic reservoir of the anti-inflammatory lipid mediator 5-palmitic acid ester of hydroxystearic acid (5-PAHSA). We found that triacylglycerol estolides were substrates of carboxyl ester lipase and 5-PAHSA-containing lipids were the least preferred substrates among tested triacylglycerol estolide isomers. This explained exceptionally high colostrum levels of 5-PAHSA in the VB group. CS and preterm birth negatively affected colostrum lipidome, including 5-PAHSA levels, but the lipidomic profiles normalized in mature milk. Mothers delivering term babies vaginally produce colostrum rich in 5-PAHSA, which could contribute to the prevention of intestinal inflammation in newborns. |
| doi_str_mv | 10.1016/j.foodchem.2022.132983 |
| format | Article |
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•Effect of preterm birth (PB) or caesarean section (CS) on milk metabolome.•Colostrum levels of 5-PAHSA were negatively affected by PB and CS.•FAHFA-containing triacylglycerols are substrates of carboxyl ester lipase in milk.•5-PAHSA-containing lipids are resistant to carboxyl ester lipase hydrolysis.
Breast milk is a complex mixture containing underexplored bioactive lipids. We performed an observational case-control study to compare the impact of delivery mode: caesarean section (CS) and vaginal birth (VB); and term (preterm and term delivery) on the levels of lipokines in human milk at different stages of lactation. Metabolomic analysis of the milk identified triacylglycerol estolides as a metabolic reservoir of the anti-inflammatory lipid mediator 5-palmitic acid ester of hydroxystearic acid (5-PAHSA). We found that triacylglycerol estolides were substrates of carboxyl ester lipase and 5-PAHSA-containing lipids were the least preferred substrates among tested triacylglycerol estolide isomers. This explained exceptionally high colostrum levels of 5-PAHSA in the VB group. CS and preterm birth negatively affected colostrum lipidome, including 5-PAHSA levels, but the lipidomic profiles normalized in mature milk. Mothers delivering term babies vaginally produce colostrum rich in 5-PAHSA, which could contribute to the prevention of intestinal inflammation in newborns.</description><identifier>ISSN: 0308-8146</identifier><identifier>EISSN: 1873-7072</identifier><identifier>DOI: 10.1016/j.foodchem.2022.132983</identifier><identifier>PMID: 35486985</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Biochemistry ; Biochemistry, Molecular Biology ; Carboxylesterase - metabolism ; Case-Control Studies ; Cesarean Section ; Colostrum ; Colostrum - metabolism ; Elective caesarean section ; Esters - metabolism ; Female ; Human breast milk ; Human health and pathology ; Humans ; Infant ; Infant, Newborn ; Lactation ; Life Sciences ; Lipase - metabolism ; Lipidomics ; Milk, Human - metabolism ; PAHSA ; Palmitic Acid - metabolism ; Pregnancy ; Premature Birth - metabolism ; Preterm birth ; Tissues and Organs ; Triglycerides - metabolism</subject><ispartof>Food chemistry, 2022-09, Vol.388, p.132983-132983, Article 132983</ispartof><rights>2022 Elsevier Ltd</rights><rights>Copyright © 2022 Elsevier Ltd. All rights reserved.</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c450t-acec5341e3fba7ad14dbd3043a596c6a660b30bcba361956da5c62e50b112f943</citedby><cites>FETCH-LOGICAL-c450t-acec5341e3fba7ad14dbd3043a596c6a660b30bcba361956da5c62e50b112f943</cites><orcidid>0000-0002-6687-3811 ; 0000-0001-6086-7296</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0308814622009451$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,776,780,881,3537,27901,27902,65534</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35486985$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.science/hal-03652917$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Brejchova, Kristyna</creatorcontrib><creatorcontrib>Paluchova, Veronika</creatorcontrib><creatorcontrib>Brezinova, Marie</creatorcontrib><creatorcontrib>Cajka, Tomas</creatorcontrib><creatorcontrib>Balas, Laurence</creatorcontrib><creatorcontrib>Durand, Thierry</creatorcontrib><creatorcontrib>Krizova, Marcela</creatorcontrib><creatorcontrib>Stranak, Zbynek</creatorcontrib><creatorcontrib>Kuda, Ondrej</creatorcontrib><title>Triacylglycerols containing branched palmitic acid ester of hydroxystearic acid (PAHSA) are present in the breast milk and hydrolyzed by carboxyl ester lipase</title><title>Food chemistry</title><addtitle>Food Chem</addtitle><description>[Display omitted]
•Effect of preterm birth (PB) or caesarean section (CS) on milk metabolome.•Colostrum levels of 5-PAHSA were negatively affected by PB and CS.•FAHFA-containing triacylglycerols are substrates of carboxyl ester lipase in milk.•5-PAHSA-containing lipids are resistant to carboxyl ester lipase hydrolysis.
Breast milk is a complex mixture containing underexplored bioactive lipids. We performed an observational case-control study to compare the impact of delivery mode: caesarean section (CS) and vaginal birth (VB); and term (preterm and term delivery) on the levels of lipokines in human milk at different stages of lactation. Metabolomic analysis of the milk identified triacylglycerol estolides as a metabolic reservoir of the anti-inflammatory lipid mediator 5-palmitic acid ester of hydroxystearic acid (5-PAHSA). We found that triacylglycerol estolides were substrates of carboxyl ester lipase and 5-PAHSA-containing lipids were the least preferred substrates among tested triacylglycerol estolide isomers. This explained exceptionally high colostrum levels of 5-PAHSA in the VB group. CS and preterm birth negatively affected colostrum lipidome, including 5-PAHSA levels, but the lipidomic profiles normalized in mature milk. Mothers delivering term babies vaginally produce colostrum rich in 5-PAHSA, which could contribute to the prevention of intestinal inflammation in newborns.</description><subject>Biochemistry</subject><subject>Biochemistry, Molecular Biology</subject><subject>Carboxylesterase - metabolism</subject><subject>Case-Control Studies</subject><subject>Cesarean Section</subject><subject>Colostrum</subject><subject>Colostrum - metabolism</subject><subject>Elective caesarean section</subject><subject>Esters - metabolism</subject><subject>Female</subject><subject>Human breast milk</subject><subject>Human health and pathology</subject><subject>Humans</subject><subject>Infant</subject><subject>Infant, Newborn</subject><subject>Lactation</subject><subject>Life Sciences</subject><subject>Lipase - metabolism</subject><subject>Lipidomics</subject><subject>Milk, Human - metabolism</subject><subject>PAHSA</subject><subject>Palmitic Acid - metabolism</subject><subject>Pregnancy</subject><subject>Premature Birth - metabolism</subject><subject>Preterm birth</subject><subject>Tissues and Organs</subject><subject>Triglycerides - metabolism</subject><issn>0308-8146</issn><issn>1873-7072</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc2O0zAUhSMEYsrAK4y8nFmk-Cdxkh3VCChSJZAY1taNfTN1ceJgpyPCw_CsuEo7W1aW7e-cc3VPlt0wumaUyfeHdee90Xvs15xyvmaCN7V4ka1YXYm8ohV_ma2ooHVes0JeZW9iPFBKOWX16-xKlEUtm7pcZX8fggU9u0c3awzeRaL9MIEd7PBI2gBDijBkBNfbyWoC2hqCccJAfEf2swn-95yuEC6ft9822--bOwIByRgw4jARO5Bpj8kOIU6kt-4ngcEscjf_SQHtTDSENpm5s72zI0R8m73qwEV8dz6vsx-fPj7cb_Pd189f7je7XBclnXLQqEtRMBRdCxUYVpjWCFoIKBupJUhJW0Fb3YKQrCmlgVJLjiVtGeNdU4jr7G7x3YNTY7A9hFl5sGq72anTGxWy5A2rnlhibxd2DP7XMU2rehs1OgcD-mNUXJY1FzwtP6FyQXXwMQbsnr0ZVace1UFdelSnHtXSYxLenDOObY_mWXYpLgEfFgDTVp4sBhW1xUGjsQH1pIy3_8v4B1zwtG8</recordid><startdate>20220915</startdate><enddate>20220915</enddate><creator>Brejchova, Kristyna</creator><creator>Paluchova, Veronika</creator><creator>Brezinova, Marie</creator><creator>Cajka, Tomas</creator><creator>Balas, Laurence</creator><creator>Durand, Thierry</creator><creator>Krizova, Marcela</creator><creator>Stranak, Zbynek</creator><creator>Kuda, Ondrej</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>1XC</scope><scope>VOOES</scope><orcidid>https://orcid.org/0000-0002-6687-3811</orcidid><orcidid>https://orcid.org/0000-0001-6086-7296</orcidid></search><sort><creationdate>20220915</creationdate><title>Triacylglycerols containing branched palmitic acid ester of hydroxystearic acid (PAHSA) are present in the breast milk and hydrolyzed by carboxyl ester lipase</title><author>Brejchova, Kristyna ; Paluchova, Veronika ; Brezinova, Marie ; Cajka, Tomas ; Balas, Laurence ; Durand, Thierry ; Krizova, Marcela ; Stranak, Zbynek ; Kuda, Ondrej</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c450t-acec5341e3fba7ad14dbd3043a596c6a660b30bcba361956da5c62e50b112f943</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Biochemistry</topic><topic>Biochemistry, Molecular Biology</topic><topic>Carboxylesterase - metabolism</topic><topic>Case-Control Studies</topic><topic>Cesarean Section</topic><topic>Colostrum</topic><topic>Colostrum - metabolism</topic><topic>Elective caesarean section</topic><topic>Esters - metabolism</topic><topic>Female</topic><topic>Human breast milk</topic><topic>Human health and pathology</topic><topic>Humans</topic><topic>Infant</topic><topic>Infant, Newborn</topic><topic>Lactation</topic><topic>Life Sciences</topic><topic>Lipase - metabolism</topic><topic>Lipidomics</topic><topic>Milk, Human - metabolism</topic><topic>PAHSA</topic><topic>Palmitic Acid - metabolism</topic><topic>Pregnancy</topic><topic>Premature Birth - metabolism</topic><topic>Preterm birth</topic><topic>Tissues and Organs</topic><topic>Triglycerides - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Brejchova, Kristyna</creatorcontrib><creatorcontrib>Paluchova, Veronika</creatorcontrib><creatorcontrib>Brezinova, Marie</creatorcontrib><creatorcontrib>Cajka, Tomas</creatorcontrib><creatorcontrib>Balas, Laurence</creatorcontrib><creatorcontrib>Durand, Thierry</creatorcontrib><creatorcontrib>Krizova, Marcela</creatorcontrib><creatorcontrib>Stranak, Zbynek</creatorcontrib><creatorcontrib>Kuda, Ondrej</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><collection>Hyper Article en Ligne (HAL) (Open Access)</collection><jtitle>Food chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Brejchova, Kristyna</au><au>Paluchova, Veronika</au><au>Brezinova, Marie</au><au>Cajka, Tomas</au><au>Balas, Laurence</au><au>Durand, Thierry</au><au>Krizova, Marcela</au><au>Stranak, Zbynek</au><au>Kuda, Ondrej</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Triacylglycerols containing branched palmitic acid ester of hydroxystearic acid (PAHSA) are present in the breast milk and hydrolyzed by carboxyl ester lipase</atitle><jtitle>Food chemistry</jtitle><addtitle>Food Chem</addtitle><date>2022-09-15</date><risdate>2022</risdate><volume>388</volume><spage>132983</spage><epage>132983</epage><pages>132983-132983</pages><artnum>132983</artnum><issn>0308-8146</issn><eissn>1873-7072</eissn><abstract>[Display omitted]
•Effect of preterm birth (PB) or caesarean section (CS) on milk metabolome.•Colostrum levels of 5-PAHSA were negatively affected by PB and CS.•FAHFA-containing triacylglycerols are substrates of carboxyl ester lipase in milk.•5-PAHSA-containing lipids are resistant to carboxyl ester lipase hydrolysis.
Breast milk is a complex mixture containing underexplored bioactive lipids. We performed an observational case-control study to compare the impact of delivery mode: caesarean section (CS) and vaginal birth (VB); and term (preterm and term delivery) on the levels of lipokines in human milk at different stages of lactation. Metabolomic analysis of the milk identified triacylglycerol estolides as a metabolic reservoir of the anti-inflammatory lipid mediator 5-palmitic acid ester of hydroxystearic acid (5-PAHSA). We found that triacylglycerol estolides were substrates of carboxyl ester lipase and 5-PAHSA-containing lipids were the least preferred substrates among tested triacylglycerol estolide isomers. This explained exceptionally high colostrum levels of 5-PAHSA in the VB group. CS and preterm birth negatively affected colostrum lipidome, including 5-PAHSA levels, but the lipidomic profiles normalized in mature milk. Mothers delivering term babies vaginally produce colostrum rich in 5-PAHSA, which could contribute to the prevention of intestinal inflammation in newborns.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>35486985</pmid><doi>10.1016/j.foodchem.2022.132983</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0002-6687-3811</orcidid><orcidid>https://orcid.org/0000-0001-6086-7296</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Food chemistry, 2022-09, Vol.388, p.132983-132983, Article 132983 |
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| subjects | Biochemistry Biochemistry, Molecular Biology Carboxylesterase - metabolism Case-Control Studies Cesarean Section Colostrum Colostrum - metabolism Elective caesarean section Esters - metabolism Female Human breast milk Human health and pathology Humans Infant Infant, Newborn Lactation Life Sciences Lipase - metabolism Lipidomics Milk, Human - metabolism PAHSA Palmitic Acid - metabolism Pregnancy Premature Birth - metabolism Preterm birth Tissues and Organs Triglycerides - metabolism |
| title | Triacylglycerols containing branched palmitic acid ester of hydroxystearic acid (PAHSA) are present in the breast milk and hydrolyzed by carboxyl ester lipase |
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