Identification of a YAC spanning the translocation breakpoint t(8;22) associated with acute monocytic leukemia

Using a series of yeast artificial chromosomes (YAC) from the 8p11‐12 chromosome region, we have analyzed a t(8;22) translocation present in two patients suffering from acute leukemia by using fluorescence in situ hybridization (FISH). We have identified a YAC that spans the breakpoint in both cases...

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Veröffentlicht in:	Genes chromosomes & cancer 1996-03, Vol.15 (3), p.191-194
Hauptverfasser:	Soenen, Valérie, Chaffanet, Max, Preudhomme, Claude, Dib, Amel, Laï, Jean-Luc, Fletcher, Jonathan A., Birnbaum, Daniel, Pébusque, Marie-Josèphe
Format:	Artikel
Sprache:	eng
Schlagworte:	Bone Marrow - pathology Cancer Chromosome Banding Chromosome Mapping Chromosomes, Artificial, Yeast Chromosomes, Human, Pair 22 Chromosomes, Human, Pair 8 Humans In Situ Hybridization, Fluorescence Karyotyping Leukemia, Monocytic, Acute - genetics Leukemia, Monocytic, Acute - pathology Leukemia, Myelomonocytic, Acute - genetics Leukemia, Myelomonocytic, Acute - pathology Life Sciences Translocation, Genetic
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Zusammenfassung:	Using a series of yeast artificial chromosomes (YAC) from the 8p11‐12 chromosome region, we have analyzed a t(8;22) translocation present in two patients suffering from acute leukemia by using fluorescence in situ hybridization (FISH). We have identified a YAC that spans the breakpoint in both cases. Genes Chromosom Cancer 15:191–194 (1996). © 1996 Wiley‐Liss, Inc.
ISSN:	1045-2257 1098-2264
DOI:	10.1002/(SICI)1098-2264(199603)15:3<191::AID-GCC9>3.0.CO;2-Y