Variant MYST4‐CBP gene fusion in a t(10;16) acute myeloid leukaemia

Summary We report a novel fusion of the MYST4 and CBP genes in an acute myeloid leukaemia (AML)‐M4 patient exhibiting t(10;16)(q22;p13) and t(11;17)(q23;q21). The t(10;16)(q22;p13) resulted in a rearrangement, where MYST4‐CBP and CBP‐MYST4 chimaeric transcripts were products of in‐frame fusions of MYST4 exon 17 to CBP exon 6 and CBP exon 4 to MYST4 exon 18 respectively. The potential resulting chimaeric proteins showed similarities with MYST3‐CBP, MYST3‐P300 and MYST3‐NCOA2 putative fusion proteins found in other cases of AML.