ETV6 gene rearrangements in invasive breast carcinoma

The ETV6/TEL gene encodes a transcription factor frequently rearranged in several types of cancer. We looked for ETV6 rearrangements in invasive breast cancer using fluorescence in situ hybridization (FISH) of BAC probes on sections of tissue microarrays containing 632 tumor samples. Of these sample...

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Veröffentlicht in:	Genes chromosomes & cancer 2005-09, Vol.44 (1), p.103-108
Hauptverfasser:	Letessier, Anne, Ginestier, Christophe, Charafe-Jauffret, Emmanuelle, Cervera, Nathalie, Adélaïde, José, Gelsi-Boyer, Véronique, Ahomadegbe, Jean-Charles, Benard, Jean, Jacquemier, Jocelyne, Birnbaum, Daniel, Chaffanet, Max
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma - genetics Adult Aged Aged, 80 and over Artificial Gene Fusion Breast Neoplasms - genetics Breast Neoplasms - pathology Cancer Centromere - genetics Chromosome Mapping DNA-Binding Proteins - genetics ETS Translocation Variant 6 Protein Female Gene Rearrangement Humans In Situ Hybridization, Fluorescence Life Sciences Middle Aged Neoplasm Invasiveness Nuclear Proteins - genetics Proto-Oncogene Proteins c-ets Repressor Proteins - genetics Telomere - genetics
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Zusammenfassung:	The ETV6/TEL gene encodes a transcription factor frequently rearranged in several types of cancer. We looked for ETV6 rearrangements in invasive breast cancer using fluorescence in situ hybridization (FISH) of BAC probes on sections of tissue microarrays containing 632 tumor samples. Of these samples, signal of sufficient quality for screening by FISH was obtained for 356. Five cases (one lobular, one nontypical secretory, one mixed, and two ductal carcinomas) showed ETV6 rearrangement. © 2005 Wiley‐Liss, Inc.
ISSN:	1045-2257 1098-2264
DOI:	10.1002/gcc.20200