High-throughput production of two disulphide-bridge toxins
A quick and efficient production method compatible with high-throughput screening was developed using 36 toxins belonging to four different families of two disulphide-bridge toxins. Final toxins were characterized using HPLC co-elution, CD and pharmacological studies.
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| Veröffentlicht in: | Chemical communications (Cambridge, England) England), 2014-08, Vol.50 (61), p.8408-8411 |
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| container_end_page | 8411 |
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| container_issue | 61 |
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| container_title | Chemical communications (Cambridge, England) |
| container_volume | 50 |
| creator | Upert, Grégory Mourier, Gilles Pastor, Alexandra Verdenaud, Marion Alili, Doria Servent, Denis Gilles, Nicolas |
| description | A quick and efficient production method compatible with high-throughput screening was developed using 36 toxins belonging to four different families of two disulphide-bridge toxins. Final toxins were characterized using HPLC co-elution, CD and pharmacological studies. |
| doi_str_mv | 10.1039/c4cc02679a |
| format | Article |
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| fulltext | fulltext |
| identifier | ISSN: 1359-7345 |
| ispartof | Chemical communications (Cambridge, England), 2014-08, Vol.50 (61), p.8408-8411 |
| issn | 1359-7345 1364-548X 1364-548X |
| language | eng |
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| source | MEDLINE; Royal Society Of Chemistry Journals 2008-; Alma/SFX Local Collection |
| subjects | Amino Acid Sequence chemical compounds chemical reactions Chromatography, High Pressure Liquid Circular Dichroism Compatibility disulfide bonds Disulfides - chemistry high performance liquid chromatography high-throughput screening methods Life Sciences Molecular Sequence Data Production methods Screening Toxins Toxins, Biological - chemistry Toxins, Biological - classification Toxins, Biological - metabolism |
| title | High-throughput production of two disulphide-bridge toxins |
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