High-throughput production of two disulphide-bridge toxins

A quick and efficient production method compatible with high-throughput screening was developed using 36 toxins belonging to four different families of two disulphide-bridge toxins. Final toxins were characterized using HPLC co-elution, CD and pharmacological studies.

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Bibliographische Detailangaben
Veröffentlicht in:	Chemical communications (Cambridge, England) England), 2014-08, Vol.50 (61), p.8408-8411
Hauptverfasser:	Upert, Grégory, Mourier, Gilles, Pastor, Alexandra, Verdenaud, Marion, Alili, Doria, Servent, Denis, Gilles, Nicolas
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence chemical compounds chemical reactions Chromatography, High Pressure Liquid Circular Dichroism Compatibility disulfide bonds Disulfides - chemistry high performance liquid chromatography high-throughput screening methods Life Sciences Molecular Sequence Data Production methods Screening Toxins Toxins, Biological - chemistry Toxins, Biological - classification Toxins, Biological - metabolism
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Beschreibung
Zusammenfassung:	A quick and efficient production method compatible with high-throughput screening was developed using 36 toxins belonging to four different families of two disulphide-bridge toxins. Final toxins were characterized using HPLC co-elution, CD and pharmacological studies.
ISSN:	1359-7345 1364-548X 1364-548X
DOI:	10.1039/c4cc02679a