Alpha-fetoprotein is a biomarker of unfolded protein response and altered proteostasis in hepatocellular carcinoma cells exposed to sorafenib

Highlights • We examine the regulation of AFP production in HCC cells exposed to sorafenib. • Sorafenib inhibits the production of AFP independently of its effect on HCC cell viability. • Sorafenib activates the Unfolded Protein Response (UPR) in HCC cells. • The production of AFP reflects the impac...

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Veröffentlicht in:	Cancer letters 2016-01, Vol.370 (2), p.242-249
Hauptverfasser:	Houessinon, Aline, Gicquel, Albane, Bochereau, Flora, Louandre, Christophe, Nyga, Rémy, Godin, Corinne, Degonville, James, Fournier, Emma, Saidak, Zuzana, Drullion, Claire, Barbare, Jean-Claude, Chauffert, Bruno, François, Catherine, Pluquet, Olivier, Galmiche, Antoine
Format:	Artikel
Sprache:	eng
Schlagworte:	Alpha-fetoprotein alpha-Fetoproteins - analysis alpha-Fetoproteins - biosynthesis Antineoplastic Agents - pharmacology Biomarkers Carcinoma, Hepatocellular - drug therapy Carcinoma, Hepatocellular - metabolism Cell Line, Tumor Cell Survival - drug effects DNA-Binding Proteins - physiology Gene expression Hematology, Oncology and Palliative Medicine Hepatocellular carcinoma Homeostasis Humans Kinases Life Sciences Liver cancer Liver Neoplasms - drug therapy Liver Neoplasms - metabolism Niacinamide - analogs & derivatives Niacinamide - pharmacology Phenylurea Compounds - pharmacology Proteins Proteins - metabolism Proteostasis Regulatory Factor X Transcription Factors Signal transduction Sorafenib Studies Transcription factors Transcription Factors - physiology Unfolded Protein Response Unfolded Protein Response (UPR)
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Zusammenfassung:	Highlights • We examine the regulation of AFP production in HCC cells exposed to sorafenib. • Sorafenib inhibits the production of AFP independently of its effect on HCC cell viability. • Sorafenib activates the Unfolded Protein Response (UPR) in HCC cells. • The production of AFP reflects the impact of sorafenib on HCC cell proteostasis.
ISSN:	0304-3835 1872-7980
DOI:	10.1016/j.canlet.2015.10.032