Home Environment as a Source of Life-Threatening Azole-Resistant Aspergillus fumigatus in Immunocompromised Patients
A case of fatal aspergillosis due to a TR46/Y121F/T289A azole-resistant Aspergillus fumigatus is reported. Environmental investigations at the patient's residence led to the recovery of TR46/Y121F/T289A isolates, genotypically indistinguishable from the clinical isolate, supporting for the firs...
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| Veröffentlicht in: | Clinical infectious diseases 2017-01, Vol.64 (1), p.76-78 |
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| container_title | Clinical infectious diseases |
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| creator | Lavergne, Rose-Anne Chouaki, Taieb Hagen, Ferry Toublanc, Bénédicte Dupont, Hervé Jounieaux, Vincent Meis, Jacques F. Morio, Florent Le Pape, Patrice |
| description | A case of fatal aspergillosis due to a TR46/Y121F/T289A azole-resistant Aspergillus fumigatus is reported. Environmental investigations at the patient's residence led to the recovery of TR46/Y121F/T289A isolates, genotypically indistinguishable from the clinical isolate, supporting for the first time the direct role of household as potential source of azole-resistant invasive aspergillosis. |
| doi_str_mv | 10.1093/cid/ciw664 |
| format | Article |
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Environmental investigations at the patient's residence led to the recovery of TR46/Y121F/T289A isolates, genotypically indistinguishable from the clinical isolate, supporting for the first time the direct role of household as potential source of azole-resistant invasive aspergillosis.</description><identifier>ISSN: 1058-4838</identifier><identifier>EISSN: 1537-6591</identifier><identifier>DOI: 10.1093/cid/ciw664</identifier><identifier>PMID: 27682064</identifier><language>eng</language><publisher>United States: Oxford University Press</publisher><subject>Aged ; Antifungal Agents - pharmacology ; Antifungal Agents - therapeutic use ; Antimicrobial agents ; Arthritis, Rheumatoid - complications ; Arthritis, Rheumatoid - drug therapy ; Aspergillosis - drug therapy ; Aspergillosis - etiology ; Aspergillus fumigatus ; Aspergillus fumigatus - drug effects ; Aspergillus fumigatus - genetics ; Azoles - pharmacology ; Azoles - therapeutic use ; BRIEF REPORTS ; Cytochrome P-450 Enzyme System - genetics ; Drug resistance ; Drug Resistance, Fungal ; Fatal Outcome ; Fungal infections ; Fungal Proteins - genetics ; Fungi ; Genotype & phenotype ; Humans ; Immunocompromised Host ; Infliximab - adverse effects ; Infliximab - therapeutic use ; Life Sciences ; Microbial Sensitivity Tests ; Mutation</subject><ispartof>Clinical infectious diseases, 2017-01, Vol.64 (1), p.76-78</ispartof><rights>Copyright © 2017 Oxford University Press on behalf of the Infectious Diseases Society of America</rights><rights>The Author 2016. 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| fulltext | fulltext |
| identifier | ISSN: 1058-4838 |
| ispartof | Clinical infectious diseases, 2017-01, Vol.64 (1), p.76-78 |
| issn | 1058-4838 1537-6591 |
| language | eng |
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| source | MEDLINE; Jstor Complete Legacy; Oxford University Press Journals All Titles (1996-Current); EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Aged Antifungal Agents - pharmacology Antifungal Agents - therapeutic use Antimicrobial agents Arthritis, Rheumatoid - complications Arthritis, Rheumatoid - drug therapy Aspergillosis - drug therapy Aspergillosis - etiology Aspergillus fumigatus Aspergillus fumigatus - drug effects Aspergillus fumigatus - genetics Azoles - pharmacology Azoles - therapeutic use BRIEF REPORTS Cytochrome P-450 Enzyme System - genetics Drug resistance Drug Resistance, Fungal Fatal Outcome Fungal infections Fungal Proteins - genetics Fungi Genotype & phenotype Humans Immunocompromised Host Infliximab - adverse effects Infliximab - therapeutic use Life Sciences Microbial Sensitivity Tests Mutation |
| title | Home Environment as a Source of Life-Threatening Azole-Resistant Aspergillus fumigatus in Immunocompromised Patients |
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