Home Environment as a Source of Life-Threatening Azole-Resistant Aspergillus fumigatus in Immunocompromised Patients

A case of fatal aspergillosis due to a TR46/Y121F/T289A azole-resistant Aspergillus fumigatus is reported. Environmental investigations at the patient's residence led to the recovery of TR46/Y121F/T289A isolates, genotypically indistinguishable from the clinical isolate, supporting for the firs...

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Veröffentlicht in:	Clinical infectious diseases 2017-01, Vol.64 (1), p.76-78
Hauptverfasser:	Lavergne, Rose-Anne, Chouaki, Taieb, Hagen, Ferry, Toublanc, Bénédicte, Dupont, Hervé, Jounieaux, Vincent, Meis, Jacques F., Morio, Florent, Le Pape, Patrice
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Antifungal Agents - pharmacology Antifungal Agents - therapeutic use Antimicrobial agents Arthritis, Rheumatoid - complications Arthritis, Rheumatoid - drug therapy Aspergillosis - drug therapy Aspergillosis - etiology Aspergillus fumigatus Aspergillus fumigatus - drug effects Aspergillus fumigatus - genetics Azoles - pharmacology Azoles - therapeutic use BRIEF REPORTS Cytochrome P-450 Enzyme System - genetics Drug resistance Drug Resistance, Fungal Fatal Outcome Fungal infections Fungal Proteins - genetics Fungi Genotype & phenotype Humans Immunocompromised Host Infliximab - adverse effects Infliximab - therapeutic use Life Sciences Microbial Sensitivity Tests Mutation
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Zusammenfassung:	A case of fatal aspergillosis due to a TR46/Y121F/T289A azole-resistant Aspergillus fumigatus is reported. Environmental investigations at the patient's residence led to the recovery of TR46/Y121F/T289A isolates, genotypically indistinguishable from the clinical isolate, supporting for the first time the direct role of household as potential source of azole-resistant invasive aspergillosis.
ISSN:	1058-4838 1537-6591
DOI:	10.1093/cid/ciw664