Multivalent presentation of a hydrolytically stable GM3 lactone mimetic as modulator of melanoma cells motility and adhesion

Multivalent presentation of a hydrolytically stable GM3 lactone mimetic as modulator of melanoma cells motility and adhesion

A hydrolytically stable mimetic of the tumour antigen GM3 lactone is used to decorate multivalent scaffolds. Two of them positively interfere on melanoma cell adhesion, migration and resistance to apoptosis (anoikis). Notably, their ability to hamper melanoma-cells adhesion and reduce the metastatic...

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Veröffentlicht in:Bioorganic & medicinal chemistry 2013-05, Vol.21 (10), p.2756-2763
Hauptverfasser: Richichi, Barbara, Comito, Giuseppina, Cerofolini, Linda, Gabrielli, Gabriele, Marra, Alberto, Moni, Lisa, Pace, Alice, Pasquato, Lucia, Chiarugi, Paola, Dondoni, Alessandro, Toma, Lucio, Nativi, Cristina
Format: Artikel
Sprache:eng
Schlagworte:
Adhesion
antigens
Apoptosis
cell adhesion
Chemical Sciences
chemistry
GM3 ganglioside
Melanoma
metastasis
Mimetic
Tumour antigen
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Zusammenfassung:A hydrolytically stable mimetic of the tumour antigen GM3 lactone is used to decorate multivalent scaffolds. Two of them positively interfere on melanoma cell adhesion, migration and resistance to apoptosis (anoikis). Notably, their ability to hamper melanoma-cells adhesion and reduce the metastatic potential is enhanced when the two scaffolds, presenting a different shape, are used in combination.
ISSN:0968-0896
0960-894X
1464-3391
DOI:10.1016/j.bmc.2013.03.021