Attenuation of Virulence by Disruption of the Mycobacterium tuberculosis erp Gene

The virulence of the mycobacteria that cause tuberculosis depends on their ability to multiply in mammalian hosts. Disruption of the bacterial erp gene, which encodes the exported repetitive protein, impaired multiplication of M. tuberculosis and M. bovis Bacille Calmette-Guerin in cultured macropha...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 1998-10, Vol.282 (5389), p.759-762
Hauptverfasser:	Berthet, Francois-Xavier, Lagranderie, Micheline, Gounon, Pierre, Laurent-Winter, Christine, Ensergueix, Danielle, Chavarot, Pierre, Thouron, Francoise, Maranghi, Eddie, Pelicic, Vladimir, Portnoï, Denis, Marchal, Gilles, Gicquel, Brigitte
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bacteria Bacterial Proteins Bacterial Proteins - analysis Bacterial Proteins - genetics Bacterial Proteins - physiology Bacteriology BCG Vaccine Biological and medical sciences Cell Line Communicable Diseases Fractions Fundamental and applied biological sciences. Psychology Genes Genes, Bacterial Genetic Complementation Test Genetics Immunohistochemistry Life Sciences Lung Lung - microbiology Lungs Macrophages Macrophages - microbiology Medical research Membrane Proteins Membrane Proteins - analysis Membrane Proteins - genetics Membrane Proteins - physiology Mice Mice, Inbred BALB C Microbiology Microbiology and Parasitology Mutation Mycobacterium bovis Mycobacterium bovis - genetics Mycobacterium bovis - growth & development Mycobacterium tuberculosis Mycobacterium tuberculosis - genetics Mycobacterium tuberculosis - growth & development Mycobacterium tuberculosis - metabolism Mycobacterium tuberculosis - pathogenicity Phagosomes Phagosomes - microbiology Recombinant Fusion Proteins Roux Spleen Tuberculosis Tuberculosis - microbiology Tuberculosis vaccine Vaccines, Attenuated Virulence Virulence - genetics
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Beschreibung
Zusammenfassung:	The virulence of the mycobacteria that cause tuberculosis depends on their ability to multiply in mammalian hosts. Disruption of the bacterial erp gene, which encodes the exported repetitive protein, impaired multiplication of M. tuberculosis and M. bovis Bacille Calmette-Guerin in cultured macrophages and mice. Reintroduction of erp into the mutants restored their ability to multiply. These results indicate that erp contributes to the virulence of M. tuberculosis.
ISSN:	0036-8075 1095-9203
DOI:	10.1126/science.282.5389.759