Recent advances in the chemistry of 1,2,4-triazoles: Synthesis, reactivity and biological activities

[Display omitted] 1,2,4-Triazoles are important heterocyclic motifs that are widely found in molecular architectures with medicinal and pharmaceutical properties. Considering the importance of these scaffolds, many works have been published over the last few decades. This review provides a focus on the synthetic approaches towards 1,2,4-triazole derivatives from common precursors such as amidines, imidates, amidrazones, aryldiazoniums and hydrazones over the last decade. This review also aims to provide an overview of triazole derivatives biological properties within the last two years.