The Polycomb landscape in mouse development

The Polycomb landscape in mouse development

Polycomb-group proteins assemble into two primary complexes—Polycomb repressive complex (PRC) 1 and 2—that safeguard cell fate by repressing gene transcription. Two new studies explore the PRC1 landscape during the transition from gametes to embryos in mice, thus providing insight into the intergene...

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Veröffentlicht in:Nature genetics 2021-04, Vol.53 (4), p.427-429
Hauptverfasser: Richard Albert, Julien, Greenberg, Maxim V. C.
Format: Artikel
Sprache:eng
Schlagworte:
631/136/2086
631/208/177
631/208/200
Agriculture
Animal Genetics and Genomics
Animals
Biomedical and Life Sciences
Biomedicine
Cancer Research
Cellular proteins
Chromatin - genetics
DNA methylation
Embryonic development
Embryos
Epigenetics
Gametocytes
Gene expression
Gene Function
Genetic aspects
Genomes
Health aspects
Histones - genetics
Human Genetics
Life Sciences
Maternal Inheritance
Mice
News & Views
news-and-views
Oocytes
Polycomb group proteins
Polycomb-Group Proteins - genetics
Polycomb-Group Proteins - metabolism
RNA polymerase
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Beschreibung
Zusammenfassung:Polycomb-group proteins assemble into two primary complexes—Polycomb repressive complex (PRC) 1 and 2—that safeguard cell fate by repressing gene transcription. Two new studies explore the PRC1 landscape during the transition from gametes to embryos in mice, thus providing insight into the intergenerational transmission of epigenetic information and gene regulation dynamics as embryos prepare for gastrulation.
ISSN:1061-4036
1546-1718
DOI:10.1038/s41588-021-00833-y