Microglia Under the Spotlight: Activity and Complement-Dependent Engulfment of Synapses

Microglia Under the Spotlight: Activity and Complement-Dependent Engulfment of Synapses

In 2012, Schaefer et al. revealed that microglia regulate the emergence of functional connectivity by engulfing and selectively eliminating synapses in the retinogeniculate system. This synaptic pruning mechanism, which is activity dependent and relies on the complement cascade, has helped define mi...

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Veröffentlicht in:Trends in neurosciences (Regular ed.) 2018-06, Vol.41 (6), p.332-334
Hauptverfasser: Thion, Morgane S., Garel, Sonia
Format: Artikel
Sprache:eng
Schlagworte:
activity
complement receptor 3
engulfment
Life Sciences
microglia
postnatal
synapses
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Zusammenfassung:In 2012, Schaefer et al. revealed that microglia regulate the emergence of functional connectivity by engulfing and selectively eliminating synapses in the retinogeniculate system. This synaptic pruning mechanism, which is activity dependent and relies on the complement cascade, has helped define microglia as a central contributor to normal wiring and to brain disorders.
ISSN:0166-2236
1878-108X
DOI:10.1016/j.tins.2018.03.017