1,2,3-Triazole-gold(I)-triethylposphine derivatives active against resistant Gram-positive pathogens

1,2,3-Triazole-gold(I)-triethylposphine derivatives active against resistant Gram-positive pathogens

To create your abstract, type over the instructions in the template box below. Fonts or abstract dimensions should not be changed or altered. [Display omitted] Innovative organogold(I) antibacterial compounds were synthesized by click chemistry with triethylphosphine-gold(I) azides and an alkyne der...

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Veröffentlicht in:Bioorganic & medicinal chemistry letters 2021-05, Vol.40, p.127879-127879, Article 127879
Hauptverfasser: Michaut, Mathieu, Steffen, Alexandre, Contreras, Jean-Marie, Morice, Christophe, Schalk, Isabelle J., Plésiat, Patrick, Mislin, Gaëtan L.A.
Format: Artikel
Sprache:eng
Schlagworte:
Antibiotic
Azide-alkyne Huisgen cycloaddition
Bacteriology
Chemical Sciences
Clostridium difficile
Enterococcus sp
Gold(I) complex
Inorganic chemistry
Life Sciences
Medicinal Chemistry
Microbiology and Parasitology
Organic chemistry
Staphylococcus sp
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Zusammenfassung:To create your abstract, type over the instructions in the template box below. Fonts or abstract dimensions should not be changed or altered. [Display omitted] Innovative organogold(I) antibacterial compounds were synthesized by click chemistry with triethylphosphine-gold(I) azides and an alkyne derivative. The resulting organo-gold(I) compounds exhibit high levels of antibacterial activity against Gram-positive pathogens, with particularly low MICs against Clostridium difficile.
ISSN:0960-894X
1464-3405
DOI:10.1016/j.bmcl.2021.127879