Specific detection of memory T-cells in COVID-19 patients using standardized whole-blood Interferon gammarelease assay. Letter to the editor

Specific detection of memory T-cells in COVID-19 patients using standardized whole-blood Interferon gammarelease assay. Letter to the editor

Antigen-specific T-cells are essential for protective immunity against SARS-CoV-2. We set up a semi-automated whole-blood Interferon-gamma release assay (WB IGRA) to monitor the T-cell response after stimulation with SARS-CoV-2 peptide pools. We report that the WB IGRA is complementary to serologica...

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Veröffentlicht in:European journal of immunology 2021-01
Hauptverfasser: Mouton, William, Compagnon, Christelle, Saker, Kahina, Daniel, Soizic, Djelabi, Sophia, Lacoux, Xavier, Pozzetto, Bruno, Oriol, Guy, Laubreton, Daphné, Prieux, Margaux, Fassier, Jean-Baptiste, Guibert, Nicolas, Massardier-Pilonchery, Amélie, Alfaiate, Dulce, Berthier, Franck, Walzer, Thierry, Marvel, Jacqueline, Brengel-Pesce, Karen, Trouiller-Assant, Sophie
Format: Artikel
Sprache:eng
Schlagworte:
Human health and pathology
Life Sciences
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Zusammenfassung:Antigen-specific T-cells are essential for protective immunity against SARS-CoV-2. We set up a semi-automated whole-blood Interferon-gamma release assay (WB IGRA) to monitor the T-cell response after stimulation with SARS-CoV-2 peptide pools. We report that the WB IGRA is complementary to serological assays to assess SARS-CoV-2 immunity.
ISSN:1521-4141
DOI:10.1002/eji.202149296