Vitamin D and white matter abnormalities in older adults: A quantitative volumetric analysis of brain MRI
Vitamin D insufficiency is associated with brain changes. Our objective was to investigate whether vitamin D insufficiency was associated with a greater volume in mm3 of white matter abnormalities (WMA) in older adults. Seventy-five Caucasian older community-dwellers (mean, 70.9±5.0years; 48%female)...
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| Veröffentlicht in: | Experimental gerontology 2015-03, Vol.63, p.41-47 |
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| creator | Annweiler, Cédric Bartha, Robert Karras, Spyridon N. Gautier, Jennifer Roche, Frédéric Beauchet, Olivier |
| description | Vitamin D insufficiency is associated with brain changes. Our objective was to investigate whether vitamin D insufficiency was associated with a greater volume in mm3 of white matter abnormalities (WMA) in older adults.
Seventy-five Caucasian older community-dwellers (mean, 70.9±5.0years; 48%female) received a blood test and brain MRI. The volumes of total white matter (WM) and WMA were measured from T1-weighted MR images using automatic, accurate and reproducible segmentation of the brain provided by FreeSurfer. Vitamin D insufficiency was defined a priori as serum 25-hydroxyvitamin D |
| doi_str_mv | 10.1016/j.exger.2015.01.049 |
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Seventy-five Caucasian older community-dwellers (mean, 70.9±5.0years; 48%female) received a blood test and brain MRI. The volumes of total white matter (WM) and WMA were measured from T1-weighted MR images using automatic, accurate and reproducible segmentation of the brain provided by FreeSurfer. Vitamin D insufficiency was defined a priori as serum 25-hydroxyvitamin D<50nmol/L. Age, gender, body mass index, mean arterial pressure, use of anti-vascular drugs, education level, Mini-Mental State Examination score, Instrumental Activities of Daily Living score, serum calcium concentration, estimated glomerular filtration rate, and season of evaluation were used as potential confounders.
Participants with vitamin D insufficiency (n=29) had a greater volume of WMA than the others (4233±4359mm3 versus 2658±1544mm3, P=0.028), even after normalization for WM volume (P=0.031). Vitamin D insufficiency was cross-sectionally associated with an increased ratio of WMA volume to WM volume (fully adjusted β=0.35, P=0.047).
Vitamin D insufficiency was associated with increased WMA volume in the studied sample of older adults. These findings may provide insight into the pathophysiology of cognitive and mobility declines in older adults with vitamin D insufficiency.
•Vitamin D, a neurosteroid hormone, is involved in neurophysiology.•Vitamin D insufficiency was associated with an increased volume of WMA in seniors.•This may explain part of cognitive and mobility disorders in this population.</description><identifier>ISSN: 0531-5565</identifier><identifier>EISSN: 1873-6815</identifier><identifier>DOI: 10.1016/j.exger.2015.01.049</identifier><identifier>PMID: 25645292</identifier><language>eng</language><publisher>England: Elsevier Inc</publisher><subject>Aged ; Aging ; Brain ; Cognitive science ; Female ; Geriatric Assessment ; Humans ; Leukoaraiosis ; Magnetic Resonance Imaging ; Male ; Older adults ; Psychology ; Radionuclide Imaging ; Vitamin D ; Vitamin D - analogs & derivatives ; Vitamin D - blood ; Vitamin D Deficiency - physiopathology ; White Matter - diagnostic imaging ; White Matter - physiopathology</subject><ispartof>Experimental gerontology, 2015-03, Vol.63, p.41-47</ispartof><rights>2015 Elsevier Inc.</rights><rights>Copyright © 2015 Elsevier Inc. All rights reserved.</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c459t-d32ad1e362686b1b4b6d28e7deff4291c56f2f989cdb961474a10a764ec56e363</citedby><cites>FETCH-LOGICAL-c459t-d32ad1e362686b1b4b6d28e7deff4291c56f2f989cdb961474a10a764ec56e363</cites><orcidid>0000-0002-7199-8109 ; 0000-0001-6115-7958 ; 0000-0003-2534-4830</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0531556515000625$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,776,780,881,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25645292$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://nantes-universite.hal.science/hal-03287648$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Annweiler, Cédric</creatorcontrib><creatorcontrib>Bartha, Robert</creatorcontrib><creatorcontrib>Karras, Spyridon N.</creatorcontrib><creatorcontrib>Gautier, Jennifer</creatorcontrib><creatorcontrib>Roche, Frédéric</creatorcontrib><creatorcontrib>Beauchet, Olivier</creatorcontrib><title>Vitamin D and white matter abnormalities in older adults: A quantitative volumetric analysis of brain MRI</title><title>Experimental gerontology</title><addtitle>Exp Gerontol</addtitle><description>Vitamin D insufficiency is associated with brain changes. Our objective was to investigate whether vitamin D insufficiency was associated with a greater volume in mm3 of white matter abnormalities (WMA) in older adults.
Seventy-five Caucasian older community-dwellers (mean, 70.9±5.0years; 48%female) received a blood test and brain MRI. The volumes of total white matter (WM) and WMA were measured from T1-weighted MR images using automatic, accurate and reproducible segmentation of the brain provided by FreeSurfer. Vitamin D insufficiency was defined a priori as serum 25-hydroxyvitamin D<50nmol/L. Age, gender, body mass index, mean arterial pressure, use of anti-vascular drugs, education level, Mini-Mental State Examination score, Instrumental Activities of Daily Living score, serum calcium concentration, estimated glomerular filtration rate, and season of evaluation were used as potential confounders.
Participants with vitamin D insufficiency (n=29) had a greater volume of WMA than the others (4233±4359mm3 versus 2658±1544mm3, P=0.028), even after normalization for WM volume (P=0.031). Vitamin D insufficiency was cross-sectionally associated with an increased ratio of WMA volume to WM volume (fully adjusted β=0.35, P=0.047).
Vitamin D insufficiency was associated with increased WMA volume in the studied sample of older adults. These findings may provide insight into the pathophysiology of cognitive and mobility declines in older adults with vitamin D insufficiency.
•Vitamin D, a neurosteroid hormone, is involved in neurophysiology.•Vitamin D insufficiency was associated with an increased volume of WMA in seniors.•This may explain part of cognitive and mobility disorders in this population.</description><subject>Aged</subject><subject>Aging</subject><subject>Brain</subject><subject>Cognitive science</subject><subject>Female</subject><subject>Geriatric Assessment</subject><subject>Humans</subject><subject>Leukoaraiosis</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Older adults</subject><subject>Psychology</subject><subject>Radionuclide Imaging</subject><subject>Vitamin D</subject><subject>Vitamin D - analogs & derivatives</subject><subject>Vitamin D - blood</subject><subject>Vitamin D Deficiency - physiopathology</subject><subject>White Matter - diagnostic imaging</subject><subject>White Matter - physiopathology</subject><issn>0531-5565</issn><issn>1873-6815</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kcFu1DAURS1ERaeFL0BCXtJFUtuxPQkSi1EptNIgJARsLcd-oR45cWs7A_17HKbtsitLz-fcJ72L0FtKakqoPN_V8Pc3xJoRKmpCa8K7F2hF23VTyZaKl2hFREMrIaQ4Ricp7QghkjX0FTpmQnLBOrZC7pfLenQT_oT1ZPGfG5cBjzpniFj3U4ij9i47SLgwwdtlbGef0we8wXeznnLxs9sD3gc_j5CjMyVJ-_vkEg4D7qMu5tfv16_R0aB9gjcP7yn6-fnyx8VVtf325fpis60MF12ubMO0pdBIJlvZ05730rIW1haGgbOOGiEHNnRtZ2zfScrXXFOi15JD-Slac4rODrk32qvb6EYd71XQTl1ttmqZkYa1hW_3tLDvD-xtDHczpKxGlwx4rycIc1JUSsI5Z3JBmwNqYkgpwvCUTYla-lA79b8PtfShCFWlj2K9e1gw9yPYJ-exgAJ8PABQTrJ3RU_GwWTAuggmKxvcswv-AWAanK4</recordid><startdate>20150301</startdate><enddate>20150301</enddate><creator>Annweiler, Cédric</creator><creator>Bartha, Robert</creator><creator>Karras, Spyridon N.</creator><creator>Gautier, Jennifer</creator><creator>Roche, Frédéric</creator><creator>Beauchet, Olivier</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>1XC</scope><orcidid>https://orcid.org/0000-0002-7199-8109</orcidid><orcidid>https://orcid.org/0000-0001-6115-7958</orcidid><orcidid>https://orcid.org/0000-0003-2534-4830</orcidid></search><sort><creationdate>20150301</creationdate><title>Vitamin D and white matter abnormalities in older adults: A quantitative volumetric analysis of brain MRI</title><author>Annweiler, Cédric ; Bartha, Robert ; Karras, Spyridon N. ; Gautier, Jennifer ; Roche, Frédéric ; Beauchet, Olivier</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c459t-d32ad1e362686b1b4b6d28e7deff4291c56f2f989cdb961474a10a764ec56e363</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Aged</topic><topic>Aging</topic><topic>Brain</topic><topic>Cognitive science</topic><topic>Female</topic><topic>Geriatric Assessment</topic><topic>Humans</topic><topic>Leukoaraiosis</topic><topic>Magnetic Resonance Imaging</topic><topic>Male</topic><topic>Older adults</topic><topic>Psychology</topic><topic>Radionuclide Imaging</topic><topic>Vitamin D</topic><topic>Vitamin D - analogs & derivatives</topic><topic>Vitamin D - blood</topic><topic>Vitamin D Deficiency - physiopathology</topic><topic>White Matter - diagnostic imaging</topic><topic>White Matter - physiopathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Annweiler, Cédric</creatorcontrib><creatorcontrib>Bartha, Robert</creatorcontrib><creatorcontrib>Karras, Spyridon N.</creatorcontrib><creatorcontrib>Gautier, Jennifer</creatorcontrib><creatorcontrib>Roche, Frédéric</creatorcontrib><creatorcontrib>Beauchet, Olivier</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><jtitle>Experimental gerontology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Annweiler, Cédric</au><au>Bartha, Robert</au><au>Karras, Spyridon N.</au><au>Gautier, Jennifer</au><au>Roche, Frédéric</au><au>Beauchet, Olivier</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Vitamin D and white matter abnormalities in older adults: A quantitative volumetric analysis of brain MRI</atitle><jtitle>Experimental gerontology</jtitle><addtitle>Exp Gerontol</addtitle><date>2015-03-01</date><risdate>2015</risdate><volume>63</volume><spage>41</spage><epage>47</epage><pages>41-47</pages><issn>0531-5565</issn><eissn>1873-6815</eissn><abstract>Vitamin D insufficiency is associated with brain changes. Our objective was to investigate whether vitamin D insufficiency was associated with a greater volume in mm3 of white matter abnormalities (WMA) in older adults.
Seventy-five Caucasian older community-dwellers (mean, 70.9±5.0years; 48%female) received a blood test and brain MRI. The volumes of total white matter (WM) and WMA were measured from T1-weighted MR images using automatic, accurate and reproducible segmentation of the brain provided by FreeSurfer. Vitamin D insufficiency was defined a priori as serum 25-hydroxyvitamin D<50nmol/L. Age, gender, body mass index, mean arterial pressure, use of anti-vascular drugs, education level, Mini-Mental State Examination score, Instrumental Activities of Daily Living score, serum calcium concentration, estimated glomerular filtration rate, and season of evaluation were used as potential confounders.
Participants with vitamin D insufficiency (n=29) had a greater volume of WMA than the others (4233±4359mm3 versus 2658±1544mm3, P=0.028), even after normalization for WM volume (P=0.031). Vitamin D insufficiency was cross-sectionally associated with an increased ratio of WMA volume to WM volume (fully adjusted β=0.35, P=0.047).
Vitamin D insufficiency was associated with increased WMA volume in the studied sample of older adults. These findings may provide insight into the pathophysiology of cognitive and mobility declines in older adults with vitamin D insufficiency.
•Vitamin D, a neurosteroid hormone, is involved in neurophysiology.•Vitamin D insufficiency was associated with an increased volume of WMA in seniors.•This may explain part of cognitive and mobility disorders in this population.</abstract><cop>England</cop><pub>Elsevier Inc</pub><pmid>25645292</pmid><doi>10.1016/j.exger.2015.01.049</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0002-7199-8109</orcidid><orcidid>https://orcid.org/0000-0001-6115-7958</orcidid><orcidid>https://orcid.org/0000-0003-2534-4830</orcidid></addata></record> |
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| ispartof | Experimental gerontology, 2015-03, Vol.63, p.41-47 |
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| subjects | Aged Aging Brain Cognitive science Female Geriatric Assessment Humans Leukoaraiosis Magnetic Resonance Imaging Male Older adults Psychology Radionuclide Imaging Vitamin D Vitamin D - analogs & derivatives Vitamin D - blood Vitamin D Deficiency - physiopathology White Matter - diagnostic imaging White Matter - physiopathology |
| title | Vitamin D and white matter abnormalities in older adults: A quantitative volumetric analysis of brain MRI |
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