Vitamin D and white matter abnormalities in older adults: A quantitative volumetric analysis of brain MRI

Vitamin D insufficiency is associated with brain changes. Our objective was to investigate whether vitamin D insufficiency was associated with a greater volume in mm3 of white matter abnormalities (WMA) in older adults. Seventy-five Caucasian older community-dwellers (mean, 70.9±5.0years; 48%female)...

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Veröffentlicht in:	Experimental gerontology 2015-03, Vol.63, p.41-47
Hauptverfasser:	Annweiler, Cédric, Bartha, Robert, Karras, Spyridon N., Gautier, Jennifer, Roche, Frédéric, Beauchet, Olivier
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Aging Brain Cognitive science Female Geriatric Assessment Humans Leukoaraiosis Magnetic Resonance Imaging Male Older adults Psychology Radionuclide Imaging Vitamin D Vitamin D - analogs & derivatives Vitamin D - blood Vitamin D Deficiency - physiopathology White Matter - diagnostic imaging White Matter - physiopathology
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Zusammenfassung:	Vitamin D insufficiency is associated with brain changes. Our objective was to investigate whether vitamin D insufficiency was associated with a greater volume in mm3 of white matter abnormalities (WMA) in older adults. Seventy-five Caucasian older community-dwellers (mean, 70.9±5.0years; 48%female) received a blood test and brain MRI. The volumes of total white matter (WM) and WMA were measured from T1-weighted MR images using automatic, accurate and reproducible segmentation of the brain provided by FreeSurfer. Vitamin D insufficiency was defined a priori as serum 25-hydroxyvitamin D
ISSN:	0531-5565 1873-6815
DOI:	10.1016/j.exger.2015.01.049