Corynebacterium diphtheriae Infection in Mahajanga, Madagascar: First Case Report

Abstract Diphtheria is an infection that has been unreported for more than two decades in Mahajanga. A child, aged 4, presented with a pseudomembranous pharyngitis was associated with a dysphagia. He was from a rural municipality of Ambato Boeny at Mahajanga province and was admitted to the Pediatri...

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Veröffentlicht in:Journal of tropical pediatrics (1980) 2021-01, Vol.67 (1)
Hauptverfasser: Rakotomalala, Rivo Solotiana, Andrianirina, Zo Zafitsara, Ratsima, Elisoa, Randrianandraina, Patrick, Randrianirina, Frédérique, Edosoa, Glenn Torrencelli, Rabenandrianina, Tahirimalala, Badell, Edgar, Toubiana, Julie, Andrianarimanana, Diavolana, Brisse, Sylvain, Rasamindrakotroka, Andry
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Sprache:eng
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Zusammenfassung:Abstract Diphtheria is an infection that has been unreported for more than two decades in Mahajanga. A child, aged 4, presented with a pseudomembranous pharyngitis was associated with a dysphagia. He was from a rural municipality of Ambato Boeny at Mahajanga province and was admitted to the Pediatric Unit of the University Hospital Center. The child was not immunized against diphtheria. A throat swab was performed and cultured, from which Corynebacterium diphtheriae was identified. The strain, of biovar Mitis, was confirmed as diphtheria toxin (DT)-gene positive and produced DT (Elek test). Unfortunately, the child developed cardiac and neurological complications and died of respiratory and heart failure.
ISSN:0142-6338
1465-3664
DOI:10.1093/tropej/fmaa064