Paternal age: Negative impact on sperm genome decays and IVF outcomes after 40 years

Paternal age: Negative impact on sperm genome decays and IVF outcomes after 40 years

This study assessed sperm quality declining on relation to paternal age and its impact on in vitro fertilization (IVF) outcomes in order to estimate the APA (Advanced Paternal Age) cutoff. For this, 83 couples undergoing IVF treatment for male factor infertility were enrolled. The women age was ≤39...

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Veröffentlicht in:Molecular reproduction and development 2018-03, Vol.85 (3), p.271-280
Hauptverfasser: Kaarouch, Ismail, Bouamoud, Nouzha, Madkour, Aicha, Louanjli, Noureddine, Saadani, Brahim, Assou, Said, Aboulmaouahib, Smahane, Amzazi, Saaid, Copin, Henri, Benkhalifa, Moncef, Sefrioui, Omar
Format: Artikel
Sprache:eng
Schlagworte:
advanced paternal age
Age
Aneuploidy
Aniline
Chromatin
DNA fragmentation
Fluorescence in situ hybridization
Genomes
In vitro fertilization
in vitro fertilization outcomes
Infertility
Life Sciences
Pregnancy
Semen
Sperm
sperm genome decays
sperm quality
Statistical analysis
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Zusammenfassung:This study assessed sperm quality declining on relation to paternal age and its impact on in vitro fertilization (IVF) outcomes in order to estimate the APA (Advanced Paternal Age) cutoff. For this, 83 couples undergoing IVF treatment for male factor infertility were enrolled. The women age was ≤39 years, whereas the men were divided in two groups: APA (n = 41; age ≥ 40 years) and young (Y) (n = 42; age
ISSN:1040-452X
1098-2795
DOI:10.1002/mrd.22963